Stem cell-ness: A "magic marker" for cancer

John P. Lahad, Gordon B. Mills, Kevin R. Coombes

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Transcriptional profiling of patient tumors is a much-heralded advancement in cancer therapy, as it provides the opportunity to identify patients who would benefit from more or less aggressive therapy and thus allows the development of individualized treatment. However, translation of this promise into patient benefit has proven challenging. In this issue of the JCI, Glinsky and colleagues used human and murine models to identify a potential stem cell mRNA signature, based on the hypothesis that tumors with stem cell-like characteristics are likely to have a poor prognosis. Remarkably, an 11-gene "expression signature" associated with "stem cell-ness" separated patients with different cancers into good- and poor-prognosis groups. Such a "magic marker" would, if validated, have a major impact on patient care. However, there remain challenges incumbent with creating and validating such signatures.

Original languageEnglish (US)
Pages (from-to)1463-1467
Number of pages5
JournalJournal of Clinical Investigation
Issue number6
StatePublished - Jun 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Stem cell-ness: A "magic marker" for cancer'. Together they form a unique fingerprint.

Cite this