TY - JOUR
T1 - Stimulatory effects of starfish sapogenins (Asterias amurensis and Lethasterias nanimensis chelifera) on molluscan heart (Spisula sachalinensis)
AU - Gorshkov, Boris A.
AU - Kapustina, Irina I.
AU - Kicha, Alla A.
AU - Aminin, Dmitry L.
AU - Gorshkova, Irina A.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998/8
Y1 - 1998/8
N2 - Sapogenins from the starfish Asterias amurensis and Lethasterias nanimensis chelifera, 5α-pregn-9(11)-ene-3β,6α-diol-20-one, 5α-cholest-9(11)-ene-3β,6α-diol-23-one, 5α-cholesta-9(11),24(25)-diene-3β,6α-diol-23-one, (20E)-5α-cholesta-9(11),20(22)-diene-3β,6α-diol-23-one and 24ξ-methyl-5α-cholesta-9(11),20(22)-diene-3β,6α-diol-23-one, stimulated the contractile force of the heart of the mollusk Spisula sachalinensis at concentration of 5x10-5 M. Ouabain, a specific inhibitor of Na+,K+-ATPase, at concentration of 5x10-5 M had no effect on this physiological model. Starfish sapogenins of the cholestane series moderately inhibited rat brain cortex Na+,K+-ATPase and decreased Ca2+ influx into Ehrlich carcinoma cells. In contrast, pregnane asterogenin asterone did not inhibit Na+,K+-ATPase and increased the influx of Ca2+ into cells. These effects were not the result of cell membrane damage, because none of the compounds tested have hemolytic activity. Copyright (C) 1998 Elsevier Science Inc.
AB - Sapogenins from the starfish Asterias amurensis and Lethasterias nanimensis chelifera, 5α-pregn-9(11)-ene-3β,6α-diol-20-one, 5α-cholest-9(11)-ene-3β,6α-diol-23-one, 5α-cholesta-9(11),24(25)-diene-3β,6α-diol-23-one, (20E)-5α-cholesta-9(11),20(22)-diene-3β,6α-diol-23-one and 24ξ-methyl-5α-cholesta-9(11),20(22)-diene-3β,6α-diol-23-one, stimulated the contractile force of the heart of the mollusk Spisula sachalinensis at concentration of 5x10-5 M. Ouabain, a specific inhibitor of Na+,K+-ATPase, at concentration of 5x10-5 M had no effect on this physiological model. Starfish sapogenins of the cholestane series moderately inhibited rat brain cortex Na+,K+-ATPase and decreased Ca2+ influx into Ehrlich carcinoma cells. In contrast, pregnane asterogenin asterone did not inhibit Na+,K+-ATPase and increased the influx of Ca2+ into cells. These effects were not the result of cell membrane damage, because none of the compounds tested have hemolytic activity. Copyright (C) 1998 Elsevier Science Inc.
KW - Asterias amurensis
KW - Asterosaponins
KW - Ca influx
KW - Contractile force
KW - Lethasterias nanimensis chelifera
KW - Molluscan heart
KW - Ouabain
KW - Rat brain Na,K-ATPase
KW - Spisula sachalinensis
KW - Starfish sapogenins
UR - http://www.scopus.com/inward/record.url?scp=0031663145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031663145&partnerID=8YFLogxK
U2 - 10.1016/S0742-8413(98)10001-4
DO - 10.1016/S0742-8413(98)10001-4
M3 - Article
C2 - 9827037
AN - SCOPUS:0031663145
SN - 0742-8413
VL - 120
SP - 235
EP - 239
JO - Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
JF - Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
IS - 2
ER -