Strain difference in pulmonary vascular responsiveness to hypoxia in rats

Jin Xian-rong; Fan Ming; Wang Zhi-qiang; Su Yun-chao; Yang Guang-tian; Hu Han-bo; Zhang Ye-ping; Feng Chang-jian; Ding Yao-xian; Wang Di-xun

doi:10.1007/BF02986450

Strain difference in pulmonary vascular responsiveness to hypoxia in rats

Jin Xian-rong, Fan Ming, Wang Zhi-qiang, Su Yun-chao, Yang Guang-tian, Hu Han-bo, Zhang Ye-ping, Feng Chang-jian, Ding Yao-xian, Wang Di-xun

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The difference in pulmonary vascular response to hypoxia between Hilltop Sprague-Dawley (HT) rats and Wistar (W) rats was studied. Effects of inhibitor of leukotriene (LT) synthesis or prostaglandin (PG) synthesis on hypoxic pulmonary vasoconstriction (HPV) and chronic pulmonary hypertension were observed, and variations in plasma TXB₂ and 6-keto-PGF_1a during hypoxia were determined. The results showed that in rats of both strains LTs are the major mediator of HPV, which is also mediated by vasoconstrictive PGs in HT rats, while modulated by vasodilative PGs in W rats. This might be the crucial mechanism responsible for the higher pulmonary vascular responsiveness in HT rats. Differences in the modulating effect of histamine and in the structural feature of pulmonary arteriole might be contributing factors as well.

Original language	English (US)
Pages (from-to)	134-140
Number of pages	7
Journal	Journal of Tongji Medical University
Volume	10
Issue number	3
DOIs	https://doi.org/10.1007/BF02986450
State	Published - Sep 1990
Externally published	Yes

Keywords

hypoxia
leukotrienes
prostaglandins
pulmonary vascular rresponsiveness

ASJC Scopus subject areas

Management of Technology and Innovation

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10.1007/BF02986450

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title = "Strain difference in pulmonary vascular responsiveness to hypoxia in rats",

abstract = "The difference in pulmonary vascular response to hypoxia between Hilltop Sprague-Dawley (HT) rats and Wistar (W) rats was studied. Effects of inhibitor of leukotriene (LT) synthesis or prostaglandin (PG) synthesis on hypoxic pulmonary vasoconstriction (HPV) and chronic pulmonary hypertension were observed, and variations in plasma TXB2 and 6-keto-PGF1a during hypoxia were determined. The results showed that in rats of both strains LTs are the major mediator of HPV, which is also mediated by vasoconstrictive PGs in HT rats, while modulated by vasodilative PGs in W rats. This might be the crucial mechanism responsible for the higher pulmonary vascular responsiveness in HT rats. Differences in the modulating effect of histamine and in the structural feature of pulmonary arteriole might be contributing factors as well.",

keywords = "hypoxia, leukotrienes, prostaglandins, pulmonary vascular rresponsiveness",

author = "Jin Xian-rong and Fan Ming and Wang Zhi-qiang and Su Yun-chao and Yang Guang-tian and Hu Han-bo and Zhang Ye-ping and Feng Chang-jian and Ding Yao-xian and Wang Di-xun",

year = "1990",

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doi = "10.1007/BF02986450",

language = "English (US)",

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TY - JOUR

T1 - Strain difference in pulmonary vascular responsiveness to hypoxia in rats

AU - Xian-rong, Jin

AU - Ming, Fan

AU - Zhi-qiang, Wang

AU - Yun-chao, Su

AU - Guang-tian, Yang

AU - Han-bo, Hu

AU - Ye-ping, Zhang

AU - Chang-jian, Feng

AU - Yao-xian, Ding

AU - Di-xun, Wang

PY - 1990/9

Y1 - 1990/9

N2 - The difference in pulmonary vascular response to hypoxia between Hilltop Sprague-Dawley (HT) rats and Wistar (W) rats was studied. Effects of inhibitor of leukotriene (LT) synthesis or prostaglandin (PG) synthesis on hypoxic pulmonary vasoconstriction (HPV) and chronic pulmonary hypertension were observed, and variations in plasma TXB2 and 6-keto-PGF1a during hypoxia were determined. The results showed that in rats of both strains LTs are the major mediator of HPV, which is also mediated by vasoconstrictive PGs in HT rats, while modulated by vasodilative PGs in W rats. This might be the crucial mechanism responsible for the higher pulmonary vascular responsiveness in HT rats. Differences in the modulating effect of histamine and in the structural feature of pulmonary arteriole might be contributing factors as well.

AB - The difference in pulmonary vascular response to hypoxia between Hilltop Sprague-Dawley (HT) rats and Wistar (W) rats was studied. Effects of inhibitor of leukotriene (LT) synthesis or prostaglandin (PG) synthesis on hypoxic pulmonary vasoconstriction (HPV) and chronic pulmonary hypertension were observed, and variations in plasma TXB2 and 6-keto-PGF1a during hypoxia were determined. The results showed that in rats of both strains LTs are the major mediator of HPV, which is also mediated by vasoconstrictive PGs in HT rats, while modulated by vasodilative PGs in W rats. This might be the crucial mechanism responsible for the higher pulmonary vascular responsiveness in HT rats. Differences in the modulating effect of histamine and in the structural feature of pulmonary arteriole might be contributing factors as well.

KW - hypoxia

KW - leukotrienes

KW - prostaglandins

KW - pulmonary vascular rresponsiveness

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JF - Journal of Tongji Medical University

IS - 3

ER -

Strain difference in pulmonary vascular responsiveness to hypoxia in rats

Abstract

Keywords

ASJC Scopus subject areas

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