Stroke associated with antiphospholipid antibodies

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46 Scopus citations


There is a strong link between antiphospholipid antibodies and stroke. Retrospective studies indicate that these patients are generally young, often have had prior thrombotic events including stroke, frequently complain of headaches, and often experience amaurosis fugax. Cardiac valvular lesions, particularly involving the mitral valve, are frequently found. The limited pathological studies show a non inflamma tory thrombotic occlusion of both large and small cerebral vessels and a “thrombotic endocarditis.” The underlying pathogenesis involves an immune-mediated prothrombotic state.

Original languageEnglish (US)
Pages (from-to)I-23-I-28
Issue number2
StatePublished - Feb 1992


  • Anticoagulants, antiphospholipid antibodies
  • Cerebrovascular disorders

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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