Subjective perception of cognition is related to mood and not performance

S. E. Marino; K. J. Meador; D. W. Loring; M. S. Okun; H. H. Fernandez; A. J. Fessler; R. P. Kustra; J. M. Miller; Patty G Ray; A. Roy; M. R. Schoenberg; V. J. Vahle; M. A. Werz

doi:10.1016/j.yebeh.2008.12.007

Subjective perception of cognition is related to mood and not performance

S. E. Marino, K. J. Meador, D. W. Loring, M. S. Okun, H. H. Fernandez, A. J. Fessler, R. P. Kustra, J. M. Miller, Patty G Ray, A. Roy, M. R. Schoenberg, V. J. Vahle, M. A. Werz

Neurology

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Objective: Clinicians monitor cognitive effects of drugs primarily by asking patients to describe their side effects. We examined the relationship of subjective perception of cognition to mood and objective cognitive performance in healthy volunteers and neurological patients. Methods: Three separate experiments used healthy adults treated with lamotrigine (LTG) and topiramate (TPM), adults with epilepsy on LTG or TPM, and patients with idiopathic Parkinson's disease. Correlations were calculated for change scores on and off drugs in the first two experiments and for the single assessment in Experiment 3. Results: Across all three experiments, significant correlations were more frequent (χ² = 259, P ≤ 0.000) for mood versus subjective cognitive perception (59%) compared with subjective versus objective cognition (2%) and mood versus objective cognitive performance (2%). Conclusions: Subjective perception of cognitive effects is related more to mood than objective performance. Clinicians should be aware of this relationship when assessing patients' cognitive complaints.

Original language	English (US)
Pages (from-to)	459-464
Number of pages	6
Journal	Epilepsy and Behavior
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/j.yebeh.2008.12.007
State	Published - Mar 2009

Keywords

Antiepileptic drugs
Cognition
Depression
Neuropsychological assessment
Parkinson's disease
Quality of life

ASJC Scopus subject areas

Neurology
Clinical Neurology
Behavioral Neuroscience

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10.1016/j.yebeh.2008.12.007

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@article{613e414acaf3471baebc2936b179caa0,

title = "Subjective perception of cognition is related to mood and not performance",

abstract = "Objective: Clinicians monitor cognitive effects of drugs primarily by asking patients to describe their side effects. We examined the relationship of subjective perception of cognition to mood and objective cognitive performance in healthy volunteers and neurological patients. Methods: Three separate experiments used healthy adults treated with lamotrigine (LTG) and topiramate (TPM), adults with epilepsy on LTG or TPM, and patients with idiopathic Parkinson's disease. Correlations were calculated for change scores on and off drugs in the first two experiments and for the single assessment in Experiment 3. Results: Across all three experiments, significant correlations were more frequent (χ2 = 259, P ≤ 0.000) for mood versus subjective cognitive perception (59%) compared with subjective versus objective cognition (2%) and mood versus objective cognitive performance (2%). Conclusions: Subjective perception of cognitive effects is related more to mood than objective performance. Clinicians should be aware of this relationship when assessing patients' cognitive complaints.",

keywords = "Antiepileptic drugs, Cognition, Depression, Neuropsychological assessment, Parkinson's disease, Quality of life",

author = "Marino, {S. E.} and Meador, {K. J.} and Loring, {D. W.} and Okun, {M. S.} and Fernandez, {H. H.} and Fessler, {A. J.} and Kustra, {R. P.} and Miller, {J. M.} and Ray, {Patty G} and A. Roy and Schoenberg, {M. R.} and Vahle, {V. J.} and Werz, {M. A.}",

note = "Funding Information: The following people performed statistical analyses: Experiment 1 (healthy volunteers)—co-author V.J. Vahle while at Washington University, St. Louis; Experiment 2 (patients with epilepsy)—A.E. Hammer, Biomedical Data Sciences, GlaxoSmithKline; Experiment 3 (Parkinson{\textquoteright}s disease)—co-author A. Roy while at the University of Florida. This work was also supported by the Center of Excellence grant from the National Parkinson Foundation and the UF INFORM-PD database. Though the actual research reported in this paper was not supported by NIH, I was being supported by an NIH grant (100% effort) via a Career Development Award (K01) during the time that I wrote the paper. Funding Information: Data from prior studies funded by GlaxoSmithKline and the INFORM PD Database, National Parkinson Foundation of Excellence, were used. ",

year = "2009",

month = mar,

doi = "10.1016/j.yebeh.2008.12.007",

language = "English (US)",

volume = "14",

pages = "459--464",

journal = "Epilepsy and Behavior",

issn = "1525-5050",

publisher = "Academic Press Inc.",

number = "3",

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TY - JOUR

T1 - Subjective perception of cognition is related to mood and not performance

AU - Marino, S. E.

AU - Meador, K. J.

AU - Loring, D. W.

AU - Okun, M. S.

AU - Fernandez, H. H.

AU - Fessler, A. J.

AU - Kustra, R. P.

AU - Miller, J. M.

AU - Ray, Patty G

AU - Roy, A.

AU - Schoenberg, M. R.

AU - Vahle, V. J.

AU - Werz, M. A.

N1 - Funding Information: The following people performed statistical analyses: Experiment 1 (healthy volunteers)—co-author V.J. Vahle while at Washington University, St. Louis; Experiment 2 (patients with epilepsy)—A.E. Hammer, Biomedical Data Sciences, GlaxoSmithKline; Experiment 3 (Parkinson’s disease)—co-author A. Roy while at the University of Florida. This work was also supported by the Center of Excellence grant from the National Parkinson Foundation and the UF INFORM-PD database. Though the actual research reported in this paper was not supported by NIH, I was being supported by an NIH grant (100% effort) via a Career Development Award (K01) during the time that I wrote the paper. Funding Information: Data from prior studies funded by GlaxoSmithKline and the INFORM PD Database, National Parkinson Foundation of Excellence, were used.

PY - 2009/3

Y1 - 2009/3

N2 - Objective: Clinicians monitor cognitive effects of drugs primarily by asking patients to describe their side effects. We examined the relationship of subjective perception of cognition to mood and objective cognitive performance in healthy volunteers and neurological patients. Methods: Three separate experiments used healthy adults treated with lamotrigine (LTG) and topiramate (TPM), adults with epilepsy on LTG or TPM, and patients with idiopathic Parkinson's disease. Correlations were calculated for change scores on and off drugs in the first two experiments and for the single assessment in Experiment 3. Results: Across all three experiments, significant correlations were more frequent (χ2 = 259, P ≤ 0.000) for mood versus subjective cognitive perception (59%) compared with subjective versus objective cognition (2%) and mood versus objective cognitive performance (2%). Conclusions: Subjective perception of cognitive effects is related more to mood than objective performance. Clinicians should be aware of this relationship when assessing patients' cognitive complaints.

AB - Objective: Clinicians monitor cognitive effects of drugs primarily by asking patients to describe their side effects. We examined the relationship of subjective perception of cognition to mood and objective cognitive performance in healthy volunteers and neurological patients. Methods: Three separate experiments used healthy adults treated with lamotrigine (LTG) and topiramate (TPM), adults with epilepsy on LTG or TPM, and patients with idiopathic Parkinson's disease. Correlations were calculated for change scores on and off drugs in the first two experiments and for the single assessment in Experiment 3. Results: Across all three experiments, significant correlations were more frequent (χ2 = 259, P ≤ 0.000) for mood versus subjective cognitive perception (59%) compared with subjective versus objective cognition (2%) and mood versus objective cognitive performance (2%). Conclusions: Subjective perception of cognitive effects is related more to mood than objective performance. Clinicians should be aware of this relationship when assessing patients' cognitive complaints.

KW - Antiepileptic drugs

KW - Cognition

KW - Depression

KW - Neuropsychological assessment

KW - Parkinson's disease

KW - Quality of life

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EP - 464

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

IS - 3

ER -

Subjective perception of cognition is related to mood and not performance

Abstract

Keywords

ASJC Scopus subject areas

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