TY - JOUR
T1 - Substance use in persons with schizophrenia
T2 - Baseline prevalence and correlates from the NIMH CATIE study
AU - Swartz, Marvin S.
AU - Wagner, H. Ryan
AU - Swanson, Jeffrey W.
AU - Stroup, T. Scott
AU - McEvoy, Joseph Patrick
AU - Canive, Jose M.
AU - Miller, Del D.
AU - Reimherr, Fred
AU - McGee, Mark
AU - Khan, Ahsan
AU - Van Dorn, Richard
AU - Rosenheck, Robert A.
AU - Lieberman, Jeffrey A.
PY - 2006/3
Y1 - 2006/3
N2 - This study examined baseline correlates of substance use in the NIMH Clinical Antipsychotic Trials of Intervention Effectiveness project. Approximately 60% of the sample was found to use substances, including 37% with current evidence of substance use disorders. Users (with and without substance use disorders), compared with nonusers, were significantly more likely to be male, be African-American, have lower educational attainment, have a recent period of homelessness, report more childhood conduct problems, have a history of major depression, have lower negative symptom and higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. Individuals with comorbid substance use disorders were significantly more likely to be male, report more childhood conduct problems, have higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. These analyses suggest that substance use disorders in schizophrenia are especially common among men with a history of childhood conduct disorder problems and that childhood conduct disorder problems are potent risk factors for substance use disorders in schizophrenia.
AB - This study examined baseline correlates of substance use in the NIMH Clinical Antipsychotic Trials of Intervention Effectiveness project. Approximately 60% of the sample was found to use substances, including 37% with current evidence of substance use disorders. Users (with and without substance use disorders), compared with nonusers, were significantly more likely to be male, be African-American, have lower educational attainment, have a recent period of homelessness, report more childhood conduct problems, have a history of major depression, have lower negative symptom and higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. Individuals with comorbid substance use disorders were significantly more likely to be male, report more childhood conduct problems, have higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. These analyses suggest that substance use disorders in schizophrenia are especially common among men with a history of childhood conduct disorder problems and that childhood conduct disorder problems are potent risk factors for substance use disorders in schizophrenia.
KW - Childhood antisocial behavior
KW - Schizophrenia
KW - Substance abuse
UR - http://www.scopus.com/inward/record.url?scp=33645104040&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645104040&partnerID=8YFLogxK
U2 - 10.1097/01.nmd.0000202575.79453.6e
DO - 10.1097/01.nmd.0000202575.79453.6e
M3 - Article
C2 - 16534433
AN - SCOPUS:33645104040
SN - 0022-3018
VL - 194
SP - 164
EP - 172
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
IS - 3
ER -