Abstract
Background: SAP102 is a scaffolding protein that regulates NMDA receptor function. Results: Specific SAP102 spliced isoform is enriched at synapses to regulate NMDA receptor surface expression. Conclusion: I2 region-containing SAP102 is required for the regulation of subunit-specificNMDAreceptor surface expression.Significance: This is the first study showing that SAP102 synaptic targeting is critical for regulating NMDAreceptor trafficking.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5105-5116 |
| Number of pages | 12 |
| Journal | Journal of Biological Chemistry |
| Volume | 290 |
| Issue number | 8 |
| DOIs | |
| State | Published - Feb 20 2015 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology