SUMO wrestling with type 1 diabetes

Manyu Li; Dehuang Guo; Carlos M. Isales; Decio L. Eizirik; Mark Atkinson; Jin Xiong She; Cong Yi Wang

doi:10.1007/s00109-005-0645-5

SUMO wrestling with type 1 diabetes

Manyu Li, Dehuang Guo, Carlos M. Isales, Decio L. Eizirik, Mark Atkinson, Jin Xiong She, Cong Yi Wang

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

Post-translational modification of proteins by phosphorylation, methylation, acetylation, or ubiquitylation represent central mechanisms through which various biological processes are regulated. Reversible covalent modification (i.e., sumoylation) of proteins by the small ubiquitin-like modifier (SUMO) has also emerged as an important mechanism contributing to the dynamic regulation of protein function. Sumoylation has been linked to the pathogenesis of a variety of disorders including Alzheimer's disease (AD), Huntington's disease (HD), and type 1 diabetes (T1D). Advances in our understanding of the role of sumoylation suggested a novel regulatory mechanism for the regulation of immune responsive gene expression. In this review, we first update recent advances in the field of sumoylation, then specifically evaluate its regulatory role in several key signaling pathways for immune response and discuss its possible implication in T1D pathogenesis.

Original language	English (US)
Pages (from-to)	504-513
Number of pages	10
Journal	Journal of Molecular Medicine
Volume	83
Issue number	7
DOIs	https://doi.org/10.1007/s00109-005-0645-5
State	Published - Jul 2005

Keywords

Autoimmunity
Immune
Regulation
SUMO
Sumoylation
Transcription

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00109-005-0645-5

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title = "SUMO wrestling with type 1 diabetes",

abstract = "Post-translational modification of proteins by phosphorylation, methylation, acetylation, or ubiquitylation represent central mechanisms through which various biological processes are regulated. Reversible covalent modification (i.e., sumoylation) of proteins by the small ubiquitin-like modifier (SUMO) has also emerged as an important mechanism contributing to the dynamic regulation of protein function. Sumoylation has been linked to the pathogenesis of a variety of disorders including Alzheimer's disease (AD), Huntington's disease (HD), and type 1 diabetes (T1D). Advances in our understanding of the role of sumoylation suggested a novel regulatory mechanism for the regulation of immune responsive gene expression. In this review, we first update recent advances in the field of sumoylation, then specifically evaluate its regulatory role in several key signaling pathways for immune response and discuss its possible implication in T1D pathogenesis.",

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author = "Manyu Li and Dehuang Guo and Isales, {Carlos M.} and Eizirik, {Decio L.} and Mark Atkinson and She, {Jin Xiong} and Wang, {Cong Yi}",

note = "Funding Information: Acknowledgements This work was supported by the CIGP program of the Medical College of Georgia, the Dean of the Medical School{\textquoteright}s special funding of the Medical College of Georgia, the Juvenile Diabetes Research Foundation International (1-2004-235), the American Diabetes Association (1-05-JF-47) to C.Y.W. and the National Institute of Child Health and Development (HD37800) to J.X.S. We thank Dr. Sarah Eckenrode for her assistance with the preparation of this manuscript.",

year = "2005",

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doi = "10.1007/s00109-005-0645-5",

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AU - Li, Manyu

AU - Guo, Dehuang

AU - Isales, Carlos M.

AU - Eizirik, Decio L.

AU - Atkinson, Mark

AU - She, Jin Xiong

AU - Wang, Cong Yi

N1 - Funding Information: Acknowledgements This work was supported by the CIGP program of the Medical College of Georgia, the Dean of the Medical School’s special funding of the Medical College of Georgia, the Juvenile Diabetes Research Foundation International (1-2004-235), the American Diabetes Association (1-05-JF-47) to C.Y.W. and the National Institute of Child Health and Development (HD37800) to J.X.S. We thank Dr. Sarah Eckenrode for her assistance with the preparation of this manuscript.

PY - 2005/7

Y1 - 2005/7

N2 - Post-translational modification of proteins by phosphorylation, methylation, acetylation, or ubiquitylation represent central mechanisms through which various biological processes are regulated. Reversible covalent modification (i.e., sumoylation) of proteins by the small ubiquitin-like modifier (SUMO) has also emerged as an important mechanism contributing to the dynamic regulation of protein function. Sumoylation has been linked to the pathogenesis of a variety of disorders including Alzheimer's disease (AD), Huntington's disease (HD), and type 1 diabetes (T1D). Advances in our understanding of the role of sumoylation suggested a novel regulatory mechanism for the regulation of immune responsive gene expression. In this review, we first update recent advances in the field of sumoylation, then specifically evaluate its regulatory role in several key signaling pathways for immune response and discuss its possible implication in T1D pathogenesis.

AB - Post-translational modification of proteins by phosphorylation, methylation, acetylation, or ubiquitylation represent central mechanisms through which various biological processes are regulated. Reversible covalent modification (i.e., sumoylation) of proteins by the small ubiquitin-like modifier (SUMO) has also emerged as an important mechanism contributing to the dynamic regulation of protein function. Sumoylation has been linked to the pathogenesis of a variety of disorders including Alzheimer's disease (AD), Huntington's disease (HD), and type 1 diabetes (T1D). Advances in our understanding of the role of sumoylation suggested a novel regulatory mechanism for the regulation of immune responsive gene expression. In this review, we first update recent advances in the field of sumoylation, then specifically evaluate its regulatory role in several key signaling pathways for immune response and discuss its possible implication in T1D pathogenesis.

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KW - Sumoylation

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SUMO wrestling with type 1 diabetes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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