TY - JOUR
T1 - Suppression of phytohemagglutinin response by fungi from a uleukemia" house
AU - Wray, Bettyb
AU - Rushing, Elisabeth J.
AU - Boyd, Rebecca C.
AU - Schindel, Ann M.
N1 - Funding Information:
This research is supported by the American Medical Association Research Fund. Submitted for publication April 26, 1978; accepted for publication September 12, 1978.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1979/9
Y1 - 1979/9
N2 - Fungal isolates from the house of a husband and wife who both developed acute myelomonocytic leukemia were assayed for effects on the in vivo response to phytohemagglutinin in guinea pigs. Skin responses to intradermal phytohemagglutinin were measured following injections of sterile fungal extracts. Isolates of Penicillium canescens, Cuyvularia, Fusarium sambucinum, Fusarium equiseti and Trichoderma koningii from the leukemia-associated house depressed the responses to phytohemagglutinin, but none of the fungal isolates obtained from a nearby control house depressed responses to phytohemagglutinin. Such environmental agents may contribute to development of malignancy by suppression of immune responses.
AB - Fungal isolates from the house of a husband and wife who both developed acute myelomonocytic leukemia were assayed for effects on the in vivo response to phytohemagglutinin in guinea pigs. Skin responses to intradermal phytohemagglutinin were measured following injections of sterile fungal extracts. Isolates of Penicillium canescens, Cuyvularia, Fusarium sambucinum, Fusarium equiseti and Trichoderma koningii from the leukemia-associated house depressed the responses to phytohemagglutinin, but none of the fungal isolates obtained from a nearby control house depressed responses to phytohemagglutinin. Such environmental agents may contribute to development of malignancy by suppression of immune responses.
UR - http://www.scopus.com/inward/record.url?scp=0018594075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018594075&partnerID=8YFLogxK
U2 - 10.1080/00039896.1979.10667430
DO - 10.1080/00039896.1979.10667430
M3 - Article
C2 - 291385
AN - SCOPUS:0018594075
SN - 1933-8244
VL - 34
SP - 350
EP - 353
JO - Archives of Environmental and Occupational Health
JF - Archives of Environmental and Occupational Health
IS - 5
ER -
