TY - JOUR
T1 - Surface-Enhanced Raman Scattering for Label-Free Living Single Cell Analysis
AU - Kuku, Gamze
AU - Altunbek, Mine
AU - Culha, Mustafa
N1 - Funding Information:
The authors acknowledge the financial support of The Scientific and Technological Council of Turkey (TUBITAK) (Project No. 113Z554) and Yeditepe University.
Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/11/7
Y1 - 2017/11/7
N2 - Single cell analysis is an active research area with the hope that cellular process can be deciphered from a single living cell other than a cell population. Surface enhanced Raman scattering (SERS) has been increasingly investigated for single cell analysis with its ability to provide information about real-time dynamics of molecular processes taking place in living cells, especially upon external stimulation, in a contactless, noninvasive, and nondestructive way. In this perspective, the fundamental concepts of single cell-SERS analysis including origin of spectral bands and experimental parameters for spectral reproducibility are summarized along with the recent developments.
AB - Single cell analysis is an active research area with the hope that cellular process can be deciphered from a single living cell other than a cell population. Surface enhanced Raman scattering (SERS) has been increasingly investigated for single cell analysis with its ability to provide information about real-time dynamics of molecular processes taking place in living cells, especially upon external stimulation, in a contactless, noninvasive, and nondestructive way. In this perspective, the fundamental concepts of single cell-SERS analysis including origin of spectral bands and experimental parameters for spectral reproducibility are summarized along with the recent developments.
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U2 - 10.1021/acs.analchem.7b03211
DO - 10.1021/acs.analchem.7b03211
M3 - Article
C2 - 29023100
AN - SCOPUS:85040699055
SN - 0003-2700
VL - 89
SP - 11160
EP - 11166
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 21
ER -