Surface-enhanced raman scattering of rat tissues

Ömer Aydin, Mehmet Kahraman, Ertuǧrul Kiliç, Mustafa Çulha

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Surface-enhanced Raman scattering (SERS) is proven to be a powerful tool for investigation of biological structures. In this study, tissues obtained from different rat organs are examined using SERS. The tissue samples are crushed with a pestle after sudden freezing in liquid nitrogen and mixed with a concentrated colloidal silver nanoparticle suspension. The reproducibility of SERS spectra acquired from several tissue samples from different organs is demonstrated. The collected spectra are comparatively evaluated based on the physiological function of the organ from which the tissue is obtained. The spectra from the tissues show significant differences and indicate that they can be used for tissue characterization and differentiation. The identification of the origins of the bands on the spectra is also attempted. This study suggests that SERS can be used to monitor the changes at the molecular level during metabolic changes in an organ or tissue as a result of a disease or another cause.

Original languageEnglish (US)
Pages (from-to)662-668
Number of pages7
JournalApplied Spectroscopy
Issue number6
StatePublished - Jun 2009
Externally publishedYes


  • Differentiation
  • Disease
  • SERS
  • Silver nanoparticles
  • Surface-enhanced Raman scattering
  • Tissue

ASJC Scopus subject areas

  • Instrumentation
  • Spectroscopy


Dive into the research topics of 'Surface-enhanced raman scattering of rat tissues'. Together they form a unique fingerprint.

Cite this