TY - JOUR
T1 - Survival of nerve allografts in sensitized rats treated with cyclosporin A
AU - Zalewski, A. A.
AU - Gulati, Adarsh K
PY - 1984/1/1
Y1 - 1984/1/1
N2 - This study examined the effect of immunosuppressive treatment with cyclosporin A (Cy-A) on the survival of nerve allografts in sensitized rats. Nerve- or skin-sensitized untreated rats rejected a second nerve allograft of the same genotype as the first in an accelerated manner. In this situation, only a few host axons grew into the proximal 1 cm of a 4 cm-long nerve allograft. However, if sensitized rats were given Cy-A (10 mg/kg daily), the second nerve allograft survived, and numerous host axons regenerated through the 4-cm length of the allograft. These results indicated that Cy-A was an effective immunosuppressive agent in sensitized rats. We conclude that, in rats donor-specific sensitization is not a contraindication to the use of nerve allografts to aid in the repair of injured nerve when Cy-A is used for immunosuppression.
AB - This study examined the effect of immunosuppressive treatment with cyclosporin A (Cy-A) on the survival of nerve allografts in sensitized rats. Nerve- or skin-sensitized untreated rats rejected a second nerve allograft of the same genotype as the first in an accelerated manner. In this situation, only a few host axons grew into the proximal 1 cm of a 4 cm-long nerve allograft. However, if sensitized rats were given Cy-A (10 mg/kg daily), the second nerve allograft survived, and numerous host axons regenerated through the 4-cm length of the allograft. These results indicated that Cy-A was an effective immunosuppressive agent in sensitized rats. We conclude that, in rats donor-specific sensitization is not a contraindication to the use of nerve allografts to aid in the repair of injured nerve when Cy-A is used for immunosuppression.
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U2 - 10.3171/jns.1984.60.4.0828
DO - 10.3171/jns.1984.60.4.0828
M3 - Article
C2 - 6368766
AN - SCOPUS:0021333255
SN - 0022-3085
VL - 60
SP - 828
EP - 834
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
IS - 4
ER -