Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates

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42 Scopus citations


Amino acid conjugates of quinolone, metronidazole and sulfadiazine antibiotics were synthesized in good yields using benzotriazole methodology. All the conjugates were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Antibiotic conjugates were tested for activity in four medically relevant organisms; Staphylococcus aureus (RN4220), Escherichia coli (DH5α), Pseudomonas aeruginosa (PAO1), and Bacillus subtilis (168). Several antibiotic conjugates show promising results against several of the strains screened.

Original languageEnglish (US)
Pages (from-to)1856-1861
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number7
StatePublished - Apr 1 2014


  • Antibacterial
  • Antibiotics
  • Benzotriazole
  • Conjugates
  • Lipophilicity

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Medicine(all)


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