Abstract
Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52-95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100 nm, similar to quinine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 361-6 |
| Number of pages | 6 |
| Journal | Chemical Biology and Drug Design |
| Volume | 82 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2013 |
Keywords
- Antimalarials
- Biological Assay
- Magnetic Resonance Spectroscopy
- Mass Spectrometry
- Peptides
- Quinine
- Journal Article