Synthesis and receptor binding of N-substituted-2-styryl-1,2,3,6-tetrahydropyridines as potential nicotinic agonists

J. Warren Beach; Christopher R. McCurdy; Mahanandeeshwar Gattu; Kenneth L. Boss; Roger E. Templeton; Alvin V. Terry

Synthesis and receptor binding of N-substituted-2-styryl-1,2,3,6-tetrahydropyridines as potential nicotinic agonists

J. Warren Beach, Christopher R. McCurdy, Mahanandeeshwar Gattu, Kenneth L. Boss, Roger E. Templeton, Alvin V. Terry

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of a series of N-substituted styryl-tetrahydropyridine derivatives is reported. The biological activity of these compounds was evaluated in vitro against both nicotinic and muscarinic receptors derived from rat cerebral cortex. The methyl derivative 6a shows binding affinity for central nicotinic receptors in the micromolar range.

Original language	English (US)
Pages (from-to)	271-281
Number of pages	11
Journal	Medicinal Chemistry Research
Volume	7
Issue number	5
State	Published - 1997

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

Cite this

@article{728ca124d3d44ad39758412557d980af,

title = "Synthesis and receptor binding of N-substituted-2-styryl-1,2,3,6-tetrahydropyridines as potential nicotinic agonists",

abstract = "The synthesis of a series of N-substituted styryl-tetrahydropyridine derivatives is reported. The biological activity of these compounds was evaluated in vitro against both nicotinic and muscarinic receptors derived from rat cerebral cortex. The methyl derivative 6a shows binding affinity for central nicotinic receptors in the micromolar range.",

author = "Beach, {J. Warren} and McCurdy, {Christopher R.} and Mahanandeeshwar Gattu and Boss, {Kenneth L.} and Templeton, {Roger E.} and Terry, {Alvin V.}",

year = "1997",

language = "English (US)",

volume = "7",

pages = "271--281",

journal = "Medicinal Chemistry Research",

issn = "1054-2523",

publisher = "Birkhause Boston",

number = "5",

}

TY - JOUR

T1 - Synthesis and receptor binding of N-substituted-2-styryl-1,2,3,6-tetrahydropyridines as potential nicotinic agonists

AU - Beach, J. Warren

AU - McCurdy, Christopher R.

AU - Gattu, Mahanandeeshwar

AU - Boss, Kenneth L.

AU - Templeton, Roger E.

AU - Terry, Alvin V.

PY - 1997

Y1 - 1997

N2 - The synthesis of a series of N-substituted styryl-tetrahydropyridine derivatives is reported. The biological activity of these compounds was evaluated in vitro against both nicotinic and muscarinic receptors derived from rat cerebral cortex. The methyl derivative 6a shows binding affinity for central nicotinic receptors in the micromolar range.

AB - The synthesis of a series of N-substituted styryl-tetrahydropyridine derivatives is reported. The biological activity of these compounds was evaluated in vitro against both nicotinic and muscarinic receptors derived from rat cerebral cortex. The methyl derivative 6a shows binding affinity for central nicotinic receptors in the micromolar range.

UR - http://www.scopus.com/inward/record.url?scp=0013475113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0013475113&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0013475113

SN - 1054-2523

VL - 7

SP - 271

EP - 281

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 5

ER -

Synthesis and receptor binding of N-substituted-2-styryl-1,2,3,6-tetrahydropyridines as potential nicotinic agonists

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this