Synthesis of taurine-containing peptides, sulfonopeptides, and N - And O -conjugates

Peter Vertesaljai; Suvendu Biswas; Iryna Lebedyeva; Evan Broggi; Abdullah M. Asiri; Alan R. Katritzky

doi:10.1021/jo500181g

Synthesis of taurine-containing peptides, sulfonopeptides, and N - And O -conjugates

Peter Vertesaljai
, Suvendu Biswas
, Iryna Lebedyeva
, Evan Broggi
, Abdullah M. Asiri
, Alan R. Katritzky

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Taurine-containing water-soluble peptidomimetics were designed and synthesized. N-terminal taurine acylations allowed synthesis of a number of taurine-containing peptides. N-protection of taurine with Cbz and SO ₂-activation with benzotriazole followed by coupling with various amino esters, dipeptides and nucleophiles provided taurine N- and O-conjugates and sulfonopeptides.

Original language	English (US)
Pages (from-to)	2688-2693
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	79
Issue number	6
DOIs	https://doi.org/10.1021/jo500181g
State	Published - Mar 21 2014
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo500181g

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abstract = "Taurine-containing water-soluble peptidomimetics were designed and synthesized. N-terminal taurine acylations allowed synthesis of a number of taurine-containing peptides. N-protection of taurine with Cbz and SO 2-activation with benzotriazole followed by coupling with various amino esters, dipeptides and nucleophiles provided taurine N- and O-conjugates and sulfonopeptides.",

author = "Peter Vertesaljai and Suvendu Biswas and Iryna Lebedyeva and Evan Broggi and Asiri, \{Abdullah M.\} and Katritzky, \{Alan R.\}",

year = "2014",

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T1 - Synthesis of taurine-containing peptides, sulfonopeptides, and N - And O -conjugates

AU - Vertesaljai, Peter

AU - Biswas, Suvendu

AU - Lebedyeva, Iryna

AU - Broggi, Evan

AU - Asiri, Abdullah M.

AU - Katritzky, Alan R.

PY - 2014/3/21

Y1 - 2014/3/21

N2 - Taurine-containing water-soluble peptidomimetics were designed and synthesized. N-terminal taurine acylations allowed synthesis of a number of taurine-containing peptides. N-protection of taurine with Cbz and SO 2-activation with benzotriazole followed by coupling with various amino esters, dipeptides and nucleophiles provided taurine N- and O-conjugates and sulfonopeptides.

AB - Taurine-containing water-soluble peptidomimetics were designed and synthesized. N-terminal taurine acylations allowed synthesis of a number of taurine-containing peptides. N-protection of taurine with Cbz and SO 2-activation with benzotriazole followed by coupling with various amino esters, dipeptides and nucleophiles provided taurine N- and O-conjugates and sulfonopeptides.

UR - https://www.scopus.com/pages/publications/84896945277

UR - https://www.scopus.com/pages/publications/84896945277#tab=citedBy

U2 - 10.1021/jo500181g

DO - 10.1021/jo500181g

M3 - Article

C2 - 24568296

AN - SCOPUS:84896945277

SN - 0022-3263

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 6

ER -

Synthesis of taurine-containing peptides, sulfonopeptides, and N - And O -conjugates

Abstract

ASJC Scopus subject areas

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