T cells can be activated by peptides that are unrelated in sequence to their selecting peptide

Leszek Ignatowicz; William Rees; Rafal Pacholczyk; Hanna Ignatowicz; Elenora Kushnir; John Kappler; Philippa Marrack

doi:10.1016/S1074-7613(00)80521-X

T cells can be activated by peptides that are unrelated in sequence to their selecting peptide

Leszek Ignatowicz, William Rees, Rafal Pacholczyk, Hanna Ignatowicz, Elenora Kushnir, John Kappler, Philippa Marrack

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

We tested the ability of CD4⁺ T cells, selected in the thymus by reaction with class II protein bound to a single peptide, to react with the same class II protein bound to other peptides. The T cells reacted with all peptides tested, including one that was quite unlike the selecting peptide in T cell receptor binding residues. The receptors on class II/peptide- reactive T cells from class II/single peptide mice were similar but not identical to some of those from normal animals. Thus, class II bound to a single peptide selects a sub-set of T cells that is related to that selected by class II bound to many peptides.

Original language	English (US)
Pages (from-to)	179-186
Number of pages	8
Journal	Immunity
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/S1074-7613(00)80521-X
State	Published - Aug 1997
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S1074-7613(00)80521-X

Cite this

@article{5806885d6e844fbf8afaacbe46b07884,

title = "T cells can be activated by peptides that are unrelated in sequence to their selecting peptide",

abstract = "We tested the ability of CD4+ T cells, selected in the thymus by reaction with class II protein bound to a single peptide, to react with the same class II protein bound to other peptides. The T cells reacted with all peptides tested, including one that was quite unlike the selecting peptide in T cell receptor binding residues. The receptors on class II/peptide- reactive T cells from class II/single peptide mice were similar but not identical to some of those from normal animals. Thus, class II bound to a single peptide selects a sub-set of T cells that is related to that selected by class II bound to many peptides.",

author = "Leszek Ignatowicz and William Rees and Rafal Pacholczyk and Hanna Ignatowicz and Elenora Kushnir and John Kappler and Philippa Marrack",

note = "Funding Information: Correspondence should be addressed to P. M. The authors thank Dean Becker for his help with animal breeding and Daphne Norsworthy for sequencing assistance. They also thank Elizabeth Bikoff, Ron Germain, Laurie Glimcher, Diane Mathis, Christophe Benoist, Charles A. Janeway, Jr., and Donal Murphy for their generous gifts of knockout mice, DNA constructs, and antibodies. This work was supported by United States Public Health Service grants AI 17134, AI-18785, and AI-22295.",

year = "1997",

month = aug,

doi = "10.1016/S1074-7613(00)80521-X",

language = "English (US)",

volume = "7",

pages = "179--186",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - T cells can be activated by peptides that are unrelated in sequence to their selecting peptide

AU - Ignatowicz, Leszek

AU - Rees, William

AU - Pacholczyk, Rafal

AU - Ignatowicz, Hanna

AU - Kushnir, Elenora

AU - Kappler, John

AU - Marrack, Philippa

N1 - Funding Information: Correspondence should be addressed to P. M. The authors thank Dean Becker for his help with animal breeding and Daphne Norsworthy for sequencing assistance. They also thank Elizabeth Bikoff, Ron Germain, Laurie Glimcher, Diane Mathis, Christophe Benoist, Charles A. Janeway, Jr., and Donal Murphy for their generous gifts of knockout mice, DNA constructs, and antibodies. This work was supported by United States Public Health Service grants AI 17134, AI-18785, and AI-22295.

PY - 1997/8

Y1 - 1997/8

N2 - We tested the ability of CD4+ T cells, selected in the thymus by reaction with class II protein bound to a single peptide, to react with the same class II protein bound to other peptides. The T cells reacted with all peptides tested, including one that was quite unlike the selecting peptide in T cell receptor binding residues. The receptors on class II/peptide- reactive T cells from class II/single peptide mice were similar but not identical to some of those from normal animals. Thus, class II bound to a single peptide selects a sub-set of T cells that is related to that selected by class II bound to many peptides.

AB - We tested the ability of CD4+ T cells, selected in the thymus by reaction with class II protein bound to a single peptide, to react with the same class II protein bound to other peptides. The T cells reacted with all peptides tested, including one that was quite unlike the selecting peptide in T cell receptor binding residues. The receptors on class II/peptide- reactive T cells from class II/single peptide mice were similar but not identical to some of those from normal animals. Thus, class II bound to a single peptide selects a sub-set of T cells that is related to that selected by class II bound to many peptides.

UR - http://www.scopus.com/inward/record.url?scp=0030865858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030865858&partnerID=8YFLogxK

U2 - 10.1016/S1074-7613(00)80521-X

DO - 10.1016/S1074-7613(00)80521-X

M3 - Article

C2 - 9285403

AN - SCOPUS:0030865858

SN - 1074-7613

VL - 7

SP - 179

EP - 186

JO - Immunity

JF - Immunity

IS - 2

ER -

T cells can be activated by peptides that are unrelated in sequence to their selecting peptide

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this