TY - JOUR
T1 - T-type calcium channels in adrenal glomerulosa cells
T2 - GTP-dependent modulation by angiotensin II
AU - McCarthy, Richard T.
AU - Isales, Carlos
AU - Rasmussen, Howard
PY - 1993/4/15
Y1 - 1993/4/15
N2 - With the use of whole-cell and single-channel current recordings, we have examined in more detail the site of action of angiotensin II (AII) on multiple populations of voltage-gated calcium channels in bovine adrenal glomerulosa cells. AII (10 nM) enhances whole-cell T-type calcium channel current and increases the activity of single T-type calcium channels in cell-attached patch recordings. The AII-induced enhancement of whole-cell calcium channel currents is dependent on the presence of internal GTP and can be inhibited by the competitive All-receptor antagonist saralasin (1 μM). These results show that AII augments the T-type calcium channel current in bovine adrenal glomerulosa cells.
AB - With the use of whole-cell and single-channel current recordings, we have examined in more detail the site of action of angiotensin II (AII) on multiple populations of voltage-gated calcium channels in bovine adrenal glomerulosa cells. AII (10 nM) enhances whole-cell T-type calcium channel current and increases the activity of single T-type calcium channels in cell-attached patch recordings. The AII-induced enhancement of whole-cell calcium channel currents is dependent on the presence of internal GTP and can be inhibited by the competitive All-receptor antagonist saralasin (1 μM). These results show that AII augments the T-type calcium channel current in bovine adrenal glomerulosa cells.
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M3 - Article
C2 - 8386369
AN - SCOPUS:0027520890
SN - 0027-8424
VL - 90
SP - 3260
EP - 3264
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 8
ER -