Targeting the vascular RhoA-Rho-kinase signaling pathway in hypertension

Cleber E. Teixeira, R. Clinton Webb

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Considerable evidence demonstrates that RhoA-Rho-kinase signaling plays an important role in various cellular functions including vascular smooth muscle contraction. Animal experiments have demonstrated a prominent role for this signaling cascade in different models of hypertension. This review describes the physiological and pathophysiological roles of the RhoA-Rho-kinase pathway, that can be considered as novel therapeutic targets in the treatment of cardiovascular diseases, such as hypertension.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalDrug Discovery Today: Therapeutic Strategies
Issue number3
StatePublished - 2005

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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