Targeting tumor microenvironment-associated cells to reverse therapy resistance

Raziye Piranlioglu; Jennifer W. Bradford; Ali Syed Arbab

doi:10.1016/B978-0-12-822527-1.00006-X

Targeting tumor microenvironment-associated cells to reverse therapy resistance

Raziye Piranlioglu
, Jennifer W. Bradford
, Ali Syed Arbab

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

About 30%-70% of the cells in any tumor are composed of noncancerous cells [1,2], with the most abundant cells in GBM coming from bone marrow-derived cells [3,4]. Although the presence of cancer-associated fibroblasts in the GBM environment is controversial, there are plentiful microglia [5-8]. Microglia are known to contribute to the immunosuppressive environment of gliomas. In this chapter, the influence of different GBM TME-associated cells (such as bone marrow derived cells) will be discussed concerning the possible cause of therapy resistance. The discussion will also involve possible ways to prevent therapy resistance due to TME-associated cells.

Original language	English (US)
Title of host publication	New Targeting in the Reversal of Resistant Glioblastomas
Publisher	Elsevier
Pages	115-144
Number of pages	30
ISBN (Electronic)	9780128225271
ISBN (Print)	9780128232767
DOIs	https://doi.org/10.1016/B978-0-12-822527-1.00006-X
State	Published - Jan 1 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bone marrow-derived cells
MDSC
Macrophages
Microglia
Myeloid cells
Platelets
T cells
Tumor microenvironment

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/B978-0-12-822527-1.00006-X

Cite this

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title = "Targeting tumor microenvironment-associated cells to reverse therapy resistance",

abstract = "About 30\%-70\% of the cells in any tumor are composed of noncancerous cells [1,2], with the most abundant cells in GBM coming from bone marrow-derived cells [3,4]. Although the presence of cancer-associated fibroblasts in the GBM environment is controversial, there are plentiful microglia [5-8]. Microglia are known to contribute to the immunosuppressive environment of gliomas. In this chapter, the influence of different GBM TME-associated cells (such as bone marrow derived cells) will be discussed concerning the possible cause of therapy resistance. The discussion will also involve possible ways to prevent therapy resistance due to TME-associated cells.",

keywords = "Bone marrow-derived cells, MDSC, Macrophages, Microglia, Myeloid cells, Platelets, T cells, Tumor microenvironment",

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T1 - Targeting tumor microenvironment-associated cells to reverse therapy resistance

AU - Piranlioglu, Raziye

AU - Bradford, Jennifer W.

AU - Arbab, Ali Syed

PY - 2021/1/1

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N2 - About 30%-70% of the cells in any tumor are composed of noncancerous cells [1,2], with the most abundant cells in GBM coming from bone marrow-derived cells [3,4]. Although the presence of cancer-associated fibroblasts in the GBM environment is controversial, there are plentiful microglia [5-8]. Microglia are known to contribute to the immunosuppressive environment of gliomas. In this chapter, the influence of different GBM TME-associated cells (such as bone marrow derived cells) will be discussed concerning the possible cause of therapy resistance. The discussion will also involve possible ways to prevent therapy resistance due to TME-associated cells.

AB - About 30%-70% of the cells in any tumor are composed of noncancerous cells [1,2], with the most abundant cells in GBM coming from bone marrow-derived cells [3,4]. Although the presence of cancer-associated fibroblasts in the GBM environment is controversial, there are plentiful microglia [5-8]. Microglia are known to contribute to the immunosuppressive environment of gliomas. In this chapter, the influence of different GBM TME-associated cells (such as bone marrow derived cells) will be discussed concerning the possible cause of therapy resistance. The discussion will also involve possible ways to prevent therapy resistance due to TME-associated cells.

KW - Bone marrow-derived cells

KW - MDSC

KW - Macrophages

KW - Microglia

KW - Myeloid cells

KW - Platelets

KW - T cells

KW - Tumor microenvironment

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DO - 10.1016/B978-0-12-822527-1.00006-X

M3 - Chapter

AN - SCOPUS:85142063220

SN - 9780128232767

SP - 115

EP - 144

BT - New Targeting in the Reversal of Resistant Glioblastomas

PB - Elsevier

ER -

Targeting tumor microenvironment-associated cells to reverse therapy resistance

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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