Targets for vascular protection after acute ischemic stroke

Susan C. Fagan, David C. Hess, Elizabeth J. Hohnadel, David M. Pollock, Adviye Ergul

Research output: Contribution to journalReview articlepeer-review

230 Scopus citations


Background-Vascular damage caused by cerebral ischemia leads to edema, hemorrhage formation, and worsened outcomes in ischemic stroke patients. Therapeutic interventions need to be developed to provide vascular protection. The purpose of this review is to identify the pathophysiologic processes involved in vascular damage after ischemia, which may lead to strategies to provide vascular protection in ischemic stroke patients. Summary of Comment-The pathologic processes caused by vascular injury after an occlusion of a cerebral artery can be separated into acute (hours), subacute (hours to days), and chronic (days to months). Targets for intervention can be identified for all 3 stages. Acutely, superoxide is the predominant mediator, followed by inflammatory mediators and proteases subacutely. In the chronic phase, proapoptotic gene products have been implicated. Conclusions-Pharmacological agents designed to target specific pathologic and protective processes affecting the vasculature should be used in clinical trials of vascular protection after acute ischemic stroke.

Original languageEnglish (US)
Pages (from-to)2220-2225
Number of pages6
Issue number9
StatePublished - Sep 2004


  • Cerebral ischemia, focal
  • Clinical trials
  • Free radicals
  • Ischemia
  • Pharmacology

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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