Tertiary lymphoid organs in human atherosclerotic plaques: Atherosclerosis

Devadatta Gosavi; Klaus Ley

doi:10.1038/s44161-025-00645-x

Tertiary lymphoid organs in human atherosclerotic plaques: Atherosclerosis

Devadatta Gosavi, Klaus Ley

Physiology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The discovery of plaque tertiary lymphoid organs (PTLOs) within human atherosclerotic plaques provides insights into the role of the immune system in atherosclerosis. The findings highlight the cellular and molecular features of PTLOs, and suggest a potential role of PTLOs in driving plaque instability by activating adaptive immune responses.

Original language	English (US)
Pages (from-to)	500-502
Number of pages	3
Journal	Nature Cardiovascular Research
Volume	4
Issue number	5
DOIs	https://doi.org/10.1038/s44161-025-00645-x
State	Published - May 2025

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology (miscellaneous)
Cell Biology
Medicine (miscellaneous)
Cardiology and Cardiovascular Medicine

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title = "Tertiary lymphoid organs in human atherosclerotic plaques: Atherosclerosis",

abstract = "The discovery of plaque tertiary lymphoid organs (PTLOs) within human atherosclerotic plaques provides insights into the role of the immune system in atherosclerosis. The findings highlight the cellular and molecular features of PTLOs, and suggest a potential role of PTLOs in driving plaque instability by activating adaptive immune responses.",

author = "Devadatta Gosavi and Klaus Ley",

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Tertiary lymphoid organs in human atherosclerotic plaques: Atherosclerosis

Abstract

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