The α4β1 integrin in sickle cell disease

J. E. Brittain; L. V. Parise

doi:10.1016/j.tracli.2008.03.013

The α4β1 integrin in sickle cell disease

J. E. Brittain, L. V. Parise

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The α4β1 integrin is an adhesion receptor expressed on reticulocytes in sickle cell disease (SCD) and mediates the adhesion of these cells to sub-endothelial matrix proteins and the endothelium. In this review, we describe the mechanism of activation of the α4β1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation. We also illustrate novel therapies in SCD that may target the integrin and alleviate vaso-occlusion.

Original language	English (US)
Pages (from-to)	19-22
Number of pages	4
Journal	Transfusion Clinique et Biologique
Volume	15
Issue number	1-2
DOIs	https://doi.org/10.1016/j.tracli.2008.03.013
State	Published - Feb 2008
Externally published	Yes

Keywords

Adhesion molecules
Sickle cell disease
Vaso-occlusion
α4β1 integrin activation

ASJC Scopus subject areas

Hematology
Clinical Biochemistry
Biochemistry, medical

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10.1016/j.tracli.2008.03.013

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title = "The α4β1 integrin in sickle cell disease",

abstract = "The α4β1 integrin is an adhesion receptor expressed on reticulocytes in sickle cell disease (SCD) and mediates the adhesion of these cells to sub-endothelial matrix proteins and the endothelium. In this review, we describe the mechanism of activation of the α4β1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation. We also illustrate novel therapies in SCD that may target the integrin and alleviate vaso-occlusion.",

keywords = "Adhesion molecules, Sickle cell disease, Vaso-occlusion, α4β1 integrin activation",

author = "Brittain, {J. E.} and Parise, {L. V.}",

year = "2008",

month = feb,

doi = "10.1016/j.tracli.2008.03.013",

language = "English (US)",

volume = "15",

pages = "19--22",

journal = "Transfusion Clinique et Biologique",

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AU - Brittain, J. E.

AU - Parise, L. V.

PY - 2008/2

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AB - The α4β1 integrin is an adhesion receptor expressed on reticulocytes in sickle cell disease (SCD) and mediates the adhesion of these cells to sub-endothelial matrix proteins and the endothelium. In this review, we describe the mechanism of activation of the α4β1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation. We also illustrate novel therapies in SCD that may target the integrin and alleviate vaso-occlusion.

KW - Adhesion molecules

KW - Sickle cell disease

KW - Vaso-occlusion

KW - α4β1 integrin activation

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JO - Transfusion Clinique et Biologique

JF - Transfusion Clinique et Biologique

IS - 1-2

ER -

The α4β1 integrin in sickle cell disease

Abstract

Keywords

ASJC Scopus subject areas

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