The α4β1 integrin in sickle cell disease

J. E. Brittain, L. V. Parise

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The α4β1 integrin is an adhesion receptor expressed on reticulocytes in sickle cell disease (SCD) and mediates the adhesion of these cells to sub-endothelial matrix proteins and the endothelium. In this review, we describe the mechanism of activation of the α4β1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation. We also illustrate novel therapies in SCD that may target the integrin and alleviate vaso-occlusion.

Original languageEnglish (US)
Pages (from-to)19-22
Number of pages4
JournalTransfusion Clinique et Biologique
Issue number1-2
StatePublished - Feb 2008
Externally publishedYes


  • Adhesion molecules
  • Sickle cell disease
  • Vaso-occlusion
  • α4β1 integrin activation

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Biochemistry, medical


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