The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani

Chad E. Stephens; Reto Brun; Manar M. Salem; Karl A. Werbovetz; Farial Tanious; W. David Wilson; David W. Boykin

doi:10.1016/S0960-894X(03)00319-6

The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani

Chad E. Stephens, Reto Brun, Manar M. Salem, Karl A. Werbovetz, Farial Tanious, W. David Wilson, David W. Boykin

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC₅₀ values of less than 1 μmol versus T. cruzi and five gave similar values versus L. donovani.

Original language	English (US)
Pages (from-to)	2065-2069
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	12
DOIs	https://doi.org/10.1016/S0960-894X(03)00319-6
State	Published - Jun 16 2003
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(03)00319-6

Cite this

@article{2c41833f429042408127446ae2ea1048,

title = "The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani",

abstract = "The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC50 values of less than 1 μmol versus T. cruzi and five gave similar values versus L. donovani.",

author = "Stephens, {Chad E.} and Reto Brun and Salem, {Manar M.} and Werbovetz, {Karl A.} and Farial Tanious and Wilson, {W. David} and Boykin, {David W.}",

note = "Funding Information: This work was supported by awards from the Bill and Melinda Gates Foundation and NIH (RO1GM61587). ",

year = "2003",

month = jun,

day = "16",

doi = "10.1016/S0960-894X(03)00319-6",

language = "English (US)",

volume = "13",

pages = "2065--2069",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "12",

}

TY - JOUR

T1 - The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani

AU - Stephens, Chad E.

AU - Brun, Reto

AU - Salem, Manar M.

AU - Werbovetz, Karl A.

AU - Tanious, Farial

AU - Wilson, W. David

AU - Boykin, David W.

N1 - Funding Information: This work was supported by awards from the Bill and Melinda Gates Foundation and NIH (RO1GM61587).

PY - 2003/6/16

Y1 - 2003/6/16

N2 - The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC50 values of less than 1 μmol versus T. cruzi and five gave similar values versus L. donovani.

AB - The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC50 values of less than 1 μmol versus T. cruzi and five gave similar values versus L. donovani.

UR - http://www.scopus.com/inward/record.url?scp=0037763899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037763899&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(03)00319-6

DO - 10.1016/S0960-894X(03)00319-6

M3 - Article

C2 - 12781196

AN - SCOPUS:0037763899

SN - 0960-894X

VL - 13

SP - 2065

EP - 2069

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 12

ER -

The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this