TY - JOUR
T1 - The association of bone, fingernail and blood manganese with cognitive and olfactory function in Chinese workers
AU - Rolle-McFarland, Danelle
AU - Liu, Yingzi
AU - Mostafaei, Farshad
AU - Zauber, S. Elizabeth
AU - Zhou, Yuanzhong
AU - Li, Yan
AU - Fan, Qiyuan
AU - Zheng, Wei
AU - Nie, Linda H.
AU - Wells, Ellen M.
N1 - Funding Information:
This study was partly supported by the Natural Science Foundation of Guizhou Province Scientific and Technology Department Grant (2017-1215); the International Scientific and Technology Cooperation Project of Guizhou Province (G2014-7012); the Innovative Talent Team Training Project of Zunyi City (2015-42); the U.S. Centers for Disease Control and Prevention, National Institute of Occupational Health Science (R21-OH010700); and the U.S. National Institutes of Health/National Institute of Environmental Health Sciences (R01-ES008146, R01-ES027078).
Funding Information:
This study was partly supported by the Natural Science Foundation of Guizhou Province Scientific and Technology Department Grant ( 2017-1215 ); the International Scientific and Technology Cooperation Project of Guizhou Province ( G2014-7012 ); the Innovative Talent Team Training Project of Zunyi City ( 2015-42 ); the U.S. Centers for Disease Control and Prevention , National Institute of Occupational Health Science ( R21-OH010700 ); and the U.S. National Institutes of Health /National Institute of Environmental Health Sciences ( R01-ES008146 , R01-ES027078 ).
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/5/20
Y1 - 2019/5/20
N2 - Occupational manganese (Mn) exposure has been associated with cognitive and olfactory dysfunction; however, few studies have incorporated cumulative biomarkers of Mn exposure such as bone Mn (BnMn). Our goal was to assess the cross-sectional association between BnMn, blood Mn (BMn), and fingernail Mn (FMn) with cognitive and olfactory function among Mn-exposed workers. A transportable in vivo neutron activation analysis (IVNAA) system was designed and utilized to assess BnMn among 60 Chinese workers. BMn and FMn were measured using inductively coupled plasma mass spectrometry. Cognitive and olfactory function was assessed using Animal and Fruit Naming tests, World Health Organization/University of California-Los Angeles Auditory Verbal Learning Test (AVLT) and the University of Pennsylvania Smell Identification Test (UPSIT). Additional data were obtained via questionnaire. Regression models adjusted for age, education, factory of employment, and smoking status (UPSIT only), were used to assess the relationship between Mn biomarkers and test scores. In adjusted models, increasing BnMn was significantly associated with decreased performance on average AVLT scores [β (95% confidence interval (CI)) = −0.65 (−1.21, −0.09)] and Animal Naming scores [β (95% CI) = −1.54 (−3.00, −0.07)]. Increasing FMn was significantly associated with reduced performance measured by the average AVLT [β (95% CI) = −0.35 (−0.70, −0.006)] and the difference in AVLT scores [β (95% CI) = −0.40 (−0.77, −0.03)]. BMn was not significantly associated with any test scores; no significant associations were observed with Fruit Naming or UPSIT tests. BnMn and FMn, but not BMn, are associated with cognitive function in Mn-exposed workers. None of the biomarkers were significantly associated with olfactory function.
AB - Occupational manganese (Mn) exposure has been associated with cognitive and olfactory dysfunction; however, few studies have incorporated cumulative biomarkers of Mn exposure such as bone Mn (BnMn). Our goal was to assess the cross-sectional association between BnMn, blood Mn (BMn), and fingernail Mn (FMn) with cognitive and olfactory function among Mn-exposed workers. A transportable in vivo neutron activation analysis (IVNAA) system was designed and utilized to assess BnMn among 60 Chinese workers. BMn and FMn were measured using inductively coupled plasma mass spectrometry. Cognitive and olfactory function was assessed using Animal and Fruit Naming tests, World Health Organization/University of California-Los Angeles Auditory Verbal Learning Test (AVLT) and the University of Pennsylvania Smell Identification Test (UPSIT). Additional data were obtained via questionnaire. Regression models adjusted for age, education, factory of employment, and smoking status (UPSIT only), were used to assess the relationship between Mn biomarkers and test scores. In adjusted models, increasing BnMn was significantly associated with decreased performance on average AVLT scores [β (95% confidence interval (CI)) = −0.65 (−1.21, −0.09)] and Animal Naming scores [β (95% CI) = −1.54 (−3.00, −0.07)]. Increasing FMn was significantly associated with reduced performance measured by the average AVLT [β (95% CI) = −0.35 (−0.70, −0.006)] and the difference in AVLT scores [β (95% CI) = −0.40 (−0.77, −0.03)]. BMn was not significantly associated with any test scores; no significant associations were observed with Fruit Naming or UPSIT tests. BnMn and FMn, but not BMn, are associated with cognitive function in Mn-exposed workers. None of the biomarkers were significantly associated with olfactory function.
KW - Biomarker
KW - Cognitive function
KW - Manganese
KW - Neutron activation analysis
KW - Olfactory function
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UR - http://www.scopus.com/inward/citedby.url?scp=85062001038&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2019.02.208
DO - 10.1016/j.scitotenv.2019.02.208
M3 - Article
C2 - 30970467
AN - SCOPUS:85062001038
SN - 0048-9697
VL - 666
SP - 1003
EP - 1010
JO - Science of the Total Environment
JF - Science of the Total Environment
ER -