The ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter-proximal nucleosomes

Boseon Byeon; Wei Wang; Artem Barski; Ryan T. Ranallo; Kan Bao; Dustin E. Schones; Keji Zhao; Carl Wu; Wei Hua Wu

doi:10.1074/jbc.M113.471979

The ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter-proximal nucleosomes

Boseon Byeon, Wei Wang, Artem Barski, Ryan T. Ranallo, Kan Bao, Dustin E. Schones, Keji Zhao, Carl Wu, Wei Hua Wu

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Background: The conserved ATP-dependent chromatin remodeling enzyme Fun30 regulates heterochromatin silencing and DNA repair. Results: Gene expression is up-regulated, and nucleosome positioning is altered in fun30Δ cells, and purified Fun30 slides nucleosome in vitro. Conclusion: Fun30 represses gene expression by sliding promoter-proximal nucleosomes. Significance: The function of Fun30 is expanded to regulation of transcription and chromatin remodeling by nucleosome sliding.

Original language	English (US)
Pages (from-to)	23182-23193
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M113.471979
State	Published - Aug 9 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.471979

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title = "The ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter-proximal nucleosomes",

abstract = "Background: The conserved ATP-dependent chromatin remodeling enzyme Fun30 regulates heterochromatin silencing and DNA repair. Results: Gene expression is up-regulated, and nucleosome positioning is altered in fun30Δ cells, and purified Fun30 slides nucleosome in vitro. Conclusion: Fun30 represses gene expression by sliding promoter-proximal nucleosomes. Significance: The function of Fun30 is expanded to regulation of transcription and chromatin remodeling by nucleosome sliding.",

author = "Boseon Byeon and Wei Wang and Artem Barski and Ranallo, {Ryan T.} and Kan Bao and Schones, {Dustin E.} and Keji Zhao and Carl Wu and Wu, {Wei Hua}",

year = "2013",

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doi = "10.1074/jbc.M113.471979",

language = "English (US)",

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T1 - The ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter-proximal nucleosomes

AU - Byeon, Boseon

AU - Wang, Wei

AU - Barski, Artem

AU - Ranallo, Ryan T.

AU - Bao, Kan

AU - Schones, Dustin E.

AU - Zhao, Keji

AU - Wu, Carl

AU - Wu, Wei Hua

PY - 2013/8/9

Y1 - 2013/8/9

N2 - Background: The conserved ATP-dependent chromatin remodeling enzyme Fun30 regulates heterochromatin silencing and DNA repair. Results: Gene expression is up-regulated, and nucleosome positioning is altered in fun30Δ cells, and purified Fun30 slides nucleosome in vitro. Conclusion: Fun30 represses gene expression by sliding promoter-proximal nucleosomes. Significance: The function of Fun30 is expanded to regulation of transcription and chromatin remodeling by nucleosome sliding.

AB - Background: The conserved ATP-dependent chromatin remodeling enzyme Fun30 regulates heterochromatin silencing and DNA repair. Results: Gene expression is up-regulated, and nucleosome positioning is altered in fun30Δ cells, and purified Fun30 slides nucleosome in vitro. Conclusion: Fun30 represses gene expression by sliding promoter-proximal nucleosomes. Significance: The function of Fun30 is expanded to regulation of transcription and chromatin remodeling by nucleosome sliding.

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JO - Journal of Biological Chemistry

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IS - 32

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The ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter-proximal nucleosomes

Abstract

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