The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts

Dane D. Jensen; Cody B. Godfrey; Christian Niklas; Meritxell Canals; Martina Kocan; Daniel P. Poole; Jane E. Murphy; Farzad Alemi; Graeme S. Cottrell; Christoph Korbmacher; Nevin A. Lambert; Nigel W. Bunnett; Carlos U. Corvera

doi:10.1074/jbc.M113.455774

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts

Dane D. Jensen, Cody B. Godfrey, Christian Niklas, Meritxell Canals, Martina Kocan, Daniel P. Poole, Jane E. Murphy, Farzad Alemi, Graeme S. Cottrell, Christoph Korbmacher, Nevin A. Lambert, Nigel W. Bunnett, Carlos U. Corvera

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with β-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.

Original language	English (US)
Pages (from-to)	22942-22960
Number of pages	19
Journal	Journal of Biological Chemistry
Volume	288
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M113.455774
State	Published - Aug 9 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Jensen, D. D., Godfrey, C. B., Niklas, C., Canals, M., Kocan, M., Poole, D. P., Murphy, J. E., Alemi, F., Cottrell, G. S., Korbmacher, C., Lambert, N. A., Bunnett, N. W., & Corvera, C. U. (2013). The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. Journal of Biological Chemistry, 288(32), 22942-22960. https://doi.org/10.1074/jbc.M113.455774

Jensen, DD, Godfrey, CB, Niklas, C, Canals, M, Kocan, M, Poole, DP, Murphy, JE, Alemi, F, Cottrell, GS, Korbmacher, C, Lambert, NA, Bunnett, NW & Corvera, CU 2013, 'The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts', Journal of Biological Chemistry, vol. 288, no. 32, pp. 22942-22960. https://doi.org/10.1074/jbc.M113.455774

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title = "The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts",

abstract = "Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with β-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.",

author = "Jensen, {Dane D.} and Godfrey, {Cody B.} and Christian Niklas and Meritxell Canals and Martina Kocan and Poole, {Daniel P.} and Murphy, {Jane E.} and Farzad Alemi and Cottrell, {Graeme S.} and Christoph Korbmacher and Lambert, {Nevin A.} and Bunnett, {Nigel W.} and Corvera, {Carlos U.}",

year = "2013",

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doi = "10.1074/jbc.M113.455774",

language = "English (US)",

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AU - Jensen, Dane D.

AU - Godfrey, Cody B.

AU - Niklas, Christian

AU - Canals, Meritxell

AU - Kocan, Martina

AU - Poole, Daniel P.

AU - Murphy, Jane E.

AU - Alemi, Farzad

AU - Cottrell, Graeme S.

AU - Korbmacher, Christoph

AU - Lambert, Nevin A.

AU - Bunnett, Nigel W.

AU - Corvera, Carlos U.

PY - 2013/8/9

Y1 - 2013/8/9

N2 - Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with β-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.

AB - Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with β-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.

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The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts

Abstract

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