Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with β-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.
|Original language||English (US)|
|Number of pages||19|
|Journal||Journal of Biological Chemistry|
|State||Published - Aug 9 2013|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology