La cellule souche cancéreuse: Un pilote aux commandes du cancer du sein

Christophe Ginestier; Hasan Korkaya; Gabriela Dontu; Daniel Birnbaum; Max S. Wicha; Emmanuelle Charafe-Jauffret

doi:10.1051/medsci/200723121133

La cellule souche cancéreuse: Un pilote aux commandes du cancer du sein

Translated title of the contribution: The cancer stem cell: The breast cancer driver

Christophe Ginestier
, Hasan Korkaya
, Gabriela Dontu
, Daniel Birnbaum
, Max S. Wicha
, Emmanuelle Charafe-Jauffret

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44⁺CD24^-/lowlin^- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.

Translated title of the contribution	The cancer stem cell: The breast cancer driver
Original language	French
Pages (from-to)	1133-1139
Number of pages	7
Journal	Medecine/Sciences
Volume	23
Issue number	12
DOIs	https://doi.org/10.1051/medsci/200723121133
State	Published - Dec 2007
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1051/medsci/200723121133

Cite this

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title = "La cellule souche canc{\'e}reuse: Un pilote aux commandes du cancer du sein",

abstract = "Recent research in a large variety of tumors, including breast cancer, has given support to the {"}cancer stem cell hypothesis{"}. Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/lowlin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.",

author = "Christophe Ginestier and Hasan Korkaya and Gabriela Dontu and Daniel Birnbaum and Wicha, \{Max S.\} and Emmanuelle Charafe-Jauffret",

year = "2007",

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doi = "10.1051/medsci/200723121133",

language = "French",

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journal = "Medecine/Sciences",

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T1 - La cellule souche cancéreuse

T2 - Un pilote aux commandes du cancer du sein

AU - Ginestier, Christophe

AU - Korkaya, Hasan

AU - Dontu, Gabriela

AU - Birnbaum, Daniel

AU - Wicha, Max S.

AU - Charafe-Jauffret, Emmanuelle

PY - 2007/12

Y1 - 2007/12

N2 - Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/lowlin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.

AB - Recent research in a large variety of tumors, including breast cancer, has given support to the "cancer stem cell hypothesis". Based on this, tumors contain and are driven by a cellular subcomponent that retains key stem cell properties. These include self-renewal, which drives tumorigenesis, and the capacity to generate cellular heterogeneity. Recently, different techniques have been used to isolate potential breast cancer stem cells with the cell surface phenotype CD44+CD24-/lowlin- or expressing Aldehyde dehydrogenase. This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future.

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UR - https://www.scopus.com/pages/publications/37849031304#tab=citedBy

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DO - 10.1051/medsci/200723121133

M3 - Review article

C2 - 18154716

AN - SCOPUS:37849031304

SN - 0767-0974

VL - 23

SP - 1133

EP - 1139

JO - Medecine/Sciences

JF - Medecine/Sciences

IS - 12

ER -

La cellule souche cancéreuse: Un pilote aux commandes du cancer du sein

Abstract

ASJC Scopus subject areas

UN SDGs

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