The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

Atanu Paul; Yenni A. Garcia; Bettina Zierer; Chaitanya Patwardhan; Omar Gutierrez; Zacariah Hildenbrand; Diondra C. Harris; Heather A. Balsiger; Jeffrey C. Sivils; Jill L. Johnson; Johannes Buchner; Ahmed Chadli; Marc B. Cox

doi:10.1074/jbc.M113.535229

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

Atanu Paul
, Yenni A. Garcia
, Bettina Zierer
, Chaitanya Patwardhan
, Omar Gutierrez
, Zacariah Hildenbrand
, Diondra C. Harris
, Heather A. Balsiger
, Jeffrey C. Sivils
, Jill L. Johnson
, Johannes Buchner
, Ahmed Chadli
, Marc B. Cox

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.

Original language	English (US)
Pages (from-to)	15297-15308
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	22
DOIs	https://doi.org/10.1074/jbc.M113.535229
State	Published - May 30 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.535229

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Paul, A., Garcia, Y. A., Zierer, B., Patwardhan, C., Gutierrez, O., Hildenbrand, Z., Harris, D. C., Balsiger, H. A., Sivils, J. C., Johnson, J. L., Buchner, J., Chadli, A., & Cox, M. B. (2014). The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors. Journal of Biological Chemistry, 289(22), 15297-15308. https://doi.org/10.1074/jbc.M113.535229

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors. / Paul, Atanu; Garcia, Yenni A.; Zierer, Bettina et al.
In: Journal of Biological Chemistry, Vol. 289, No. 22, 30.05.2014, p. 15297-15308.

Research output: Contribution to journal › Article › peer-review

Paul, A, Garcia, YA, Zierer, B, Patwardhan, C, Gutierrez, O, Hildenbrand, Z, Harris, DC, Balsiger, HA, Sivils, JC, Johnson, JL, Buchner, J, Chadli, A & Cox, MB 2014, 'The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors', Journal of Biological Chemistry, vol. 289, no. 22, pp. 15297-15308. https://doi.org/10.1074/jbc.M113.535229

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title = "The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors",

abstract = "Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.",

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AU - Zierer, Bettina

AU - Patwardhan, Chaitanya

AU - Gutierrez, Omar

AU - Hildenbrand, Zacariah

AU - Harris, Diondra C.

AU - Balsiger, Heather A.

AU - Sivils, Jeffrey C.

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AU - Buchner, Johannes

AU - Chadli, Ahmed

AU - Cox, Marc B.

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The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

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