The complement cascade as a mediator of tissue growth and regeneration

Martin J. Rutkowski, Michael E. Sughrue, Ari J. Kane, Brian J. Ahn, Shanna Fang, Andrew T. Parsa

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations


Recent evidence has demonstrated that the complement cascade is involved in a variety of physiologic and pathophysiologic processes in addition to its role as an immune effector. Research in a variety of organ systems has shown that complement proteins are direct participants in maintenance of cellular turnover, healing, proliferation and regeneration. As a physiologic housekeeper, complement proteins maintain tissue integrity in the absence of inflammation by disposing of cellular debris and waste, a process critical to the prevention of autoimmune disease. Developmentally, complement proteins influence pathways including hematopoietic stem cell engraftment, bone growth, and angiogenesis. They also provide a potent stimulus for cellular proliferation including regeneration of the limb and eye in animal models, and liver proliferation following injury. Here, we describe the complement cascade as a mediator of tissue growth and regeneration.

Original languageEnglish (US)
Pages (from-to)897-905
Number of pages9
JournalInflammation Research
Issue number11
StatePublished - Nov 2010
Externally publishedYes


  • Complement
  • Growth
  • Healing
  • Proliferation
  • Regeneration

ASJC Scopus subject areas

  • Immunology
  • Pharmacology


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