The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity

Jennifer A. Thompson; Trevor A. Hardigan; Maria Alicia Carrillo-Sepulveda; James D. Mintz; Adviye Ergul; Michael P. Diamond; R. Clinton Webb

doi:10.1016/j.placenta.2015.07.132

The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity

Jennifer A. Thompson, Trevor A. Hardigan, Maria Alicia Carrillo-Sepulveda, James D. Mintz, Adviye Ergul, Michael P. Diamond, R. Clinton Webb

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Toll-like receptor (TLR)-regulated protein kinases and inflammatory cytokines were activated in fetal vascular smooth muscle cells (VSMC) treated with palmitate. Tumor necrosis factor (TNFα) and interleukin-6 (IL6) were increased and correlated with expression of TLRs in the labyrinth placentae of high fat (HF)-fed rats with increased plasma lipids and visceral adiposity. Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.

Original language	English (US)
Pages (from-to)	1204-1206
Number of pages	3
Journal	Placenta
Volume	36
Issue number	10
DOIs	https://doi.org/10.1016/j.placenta.2015.07.132
State	E-pub ahead of print - Aug 6 2015

Keywords

Maternal obesity
Placental inflammation
Toll-like receptors

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.placenta.2015.07.132

Cite this

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title = "The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity",

abstract = "Toll-like receptor (TLR)-regulated protein kinases and inflammatory cytokines were activated in fetal vascular smooth muscle cells (VSMC) treated with palmitate. Tumor necrosis factor (TNFα) and interleukin-6 (IL6) were increased and correlated with expression of TLRs in the labyrinth placentae of high fat (HF)-fed rats with increased plasma lipids and visceral adiposity. Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.",

keywords = "Maternal obesity, Placental inflammation, Toll-like receptors",

author = "Thompson, {Jennifer A.} and Hardigan, {Trevor A.} and Carrillo-Sepulveda, {Maria Alicia} and Mintz, {James D.} and Adviye Ergul and Diamond, {Michael P.} and Webb, {R. Clinton}",

note = "Funding Information: We would like to thank Dr. Stella Goulopoulou for reading the proposal and providing input and Safia Ogbi for general assistance in the laboratory. This research was funded by the Society for Women's Health Research . Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",

year = "2015",

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doi = "10.1016/j.placenta.2015.07.132",

language = "English (US)",

volume = "36",

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AU - Thompson, Jennifer A.

AU - Hardigan, Trevor A.

AU - Carrillo-Sepulveda, Maria Alicia

AU - Mintz, James D.

AU - Ergul, Adviye

AU - Diamond, Michael P.

AU - Webb, R. Clinton

N1 - Funding Information: We would like to thank Dr. Stella Goulopoulou for reading the proposal and providing input and Safia Ogbi for general assistance in the laboratory. This research was funded by the Society for Women's Health Research . Publisher Copyright: © 2015 Elsevier Ltd. All rights reserved.

PY - 2015/8/6

Y1 - 2015/8/6

N2 - Toll-like receptor (TLR)-regulated protein kinases and inflammatory cytokines were activated in fetal vascular smooth muscle cells (VSMC) treated with palmitate. Tumor necrosis factor (TNFα) and interleukin-6 (IL6) were increased and correlated with expression of TLRs in the labyrinth placentae of high fat (HF)-fed rats with increased plasma lipids and visceral adiposity. Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.

AB - Toll-like receptor (TLR)-regulated protein kinases and inflammatory cytokines were activated in fetal vascular smooth muscle cells (VSMC) treated with palmitate. Tumor necrosis factor (TNFα) and interleukin-6 (IL6) were increased and correlated with expression of TLRs in the labyrinth placentae of high fat (HF)-fed rats with increased plasma lipids and visceral adiposity. Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.

KW - Maternal obesity

KW - Placental inflammation

KW - Toll-like receptors

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The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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