The Diagnosis of Acute Glomerulonephritis

Michael P. Madaio, John T. Harrington

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


WE define acute glomerulonephritis as the sudden appearance of hematuria, proteinuria, and red-cell casts. The last finding, which rarely occurs in other types of renal disease,1 is virtually diagnostic of active glomerular inflammation. The clinician should carefully examine the urinary sediment for red-cell casts and should not delegate this critical test to the laboratory performing routine urinalysis. In the absence of such casts, dysmorphic red cells in the urine viewed under a phase-contrast microscope have also been shown to correlate closely with active glomerular disease.2 Hematuria, which is virtually always present, can be persistent or intermittent, gross or microscopic. Proteinuria.

Original languageEnglish (US)
Pages (from-to)1299-1302
Number of pages4
JournalNew England Journal of Medicine
Issue number21
StatePublished - Nov 24 1983
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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