The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application

Leyuan Xu; Natasha Sheybani; W. Andrew Yeudall; Hu Yang

doi:10.1039/c4bm00245h

The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application

Leyuan Xu, Natasha Sheybani, W. Andrew Yeudall, Hu Yang

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Free-radical photopolymerization initiated by photoinitiators is an important method to make tissue engineering scaffolds. To advance understanding of photoinitiator cytocompatibility, we examined three photoinitiators including 2,2-dimethoxy-2-phenylacetophenone (DMPA), Irgacure 2959 (I-2959), and eosin Y photoinitiating system (EY) in terms of their effects on the viability of HN4 cells and expression levels of intracellular AKT and its phosphorylated form p-AKT. Our results show that the photoinitiators and their UV-exposed counterparts affect intracellular AKT signaling, which can be used in conjunction with cell viability for cytocompatibility assessment of photoinitiators.

Original language	English (US)
Pages (from-to)	250-255
Number of pages	6
Journal	Biomaterials Science
Volume	3
Issue number	2
DOIs	https://doi.org/10.1039/c4bm00245h
State	Published - Feb 1 2015
Externally published	Yes

ASJC Scopus subject areas

Biomedical Engineering
General Materials Science

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title = "The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application",

abstract = "Free-radical photopolymerization initiated by photoinitiators is an important method to make tissue engineering scaffolds. To advance understanding of photoinitiator cytocompatibility, we examined three photoinitiators including 2,2-dimethoxy-2-phenylacetophenone (DMPA), Irgacure 2959 (I-2959), and eosin Y photoinitiating system (EY) in terms of their effects on the viability of HN4 cells and expression levels of intracellular AKT and its phosphorylated form p-AKT. Our results show that the photoinitiators and their UV-exposed counterparts affect intracellular AKT signaling, which can be used in conjunction with cell viability for cytocompatibility assessment of photoinitiators.",

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AU - Xu, Leyuan

AU - Sheybani, Natasha

AU - Yeudall, W. Andrew

AU - Yang, Hu

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

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AB - Free-radical photopolymerization initiated by photoinitiators is an important method to make tissue engineering scaffolds. To advance understanding of photoinitiator cytocompatibility, we examined three photoinitiators including 2,2-dimethoxy-2-phenylacetophenone (DMPA), Irgacure 2959 (I-2959), and eosin Y photoinitiating system (EY) in terms of their effects on the viability of HN4 cells and expression levels of intracellular AKT and its phosphorylated form p-AKT. Our results show that the photoinitiators and their UV-exposed counterparts affect intracellular AKT signaling, which can be used in conjunction with cell viability for cytocompatibility assessment of photoinitiators.

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The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application

Abstract

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