The effect of QMix, an experimental antibacterial root canal irrigant, on removal of canal wall smear layer and debris

Lin Dai, Khaled Khechen, Sara Khan, Brian Gillen, Bethany A. Loushine, Courtney E. Wimmer, James L. Gutmann, David Pashley, Franklin R. Tay

Research output: Contribution to journalArticlepeer-review

122 Scopus citations


Introduction: This study examined the ability of two versions of QMix, an experimental antimicrobial irrigant, on removal of canal wall smear layers and debris using an open canal design. Methods: Cleaned and shaped single-rooted human root canals were irrigated with NaOCl as the initial irrigant and one of the following as the final irrigant: (1) QMix I (pH = 8), (2) QMix II (pH = 7.5), (3) distilled water, (4) 17% EDTA, and (5) BioPure MTAD (Dentsply Tulsa Dental Specialties, Tulsa, OK). Smear and debris scores were evaluated in the coronal, middle, and apical thirds of longitudinally fractured canal spaces using scanning electron microscopy and analyzed using Cochran-Mantel-Haenszel statistic. Results: Smear scores, when the overall canal was considered, differences were observed among groups except groups 1 versus 4 and groups 2 versus 4. After adjusting for canal levels, all groups differed significantly from each other (p < 0.005) with the exception of groups 2 versus 5. For the debris scores, no significant difference was observed among the treatment groups when the overall canal was considered and after adjusting for the effect of canal level. Conclusion: Within the limitations of an open-canal design, the two experimental QMix versions are as effective as 17% EDTA in removing canal wall smear layers after the use of 5.25% NaOCl as the initial rinse.

Original languageEnglish (US)
Pages (from-to)80-84
Number of pages5
JournalJournal of endodontics
Issue number1
StatePublished - Jan 2011


  • Antimicrobial
  • canal level
  • chelation
  • debris
  • root canal irrigant
  • smear layer
  • surfactant

ASJC Scopus subject areas

  • General Dentistry


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