The effects of fluoride on the gastric mucosa of the rat

D. H. Pashley; N. B. Allison; R. P. Easmann; R. V. McKinney; J. A. Horner; G. M. Whitford

doi:10.1111/j.1600-0714.1984.tb01454.x

The effects of fluoride on the gastric mucosa of the rat

D. H. Pashley, N. B. Allison, R. P. Easmann, R. V. McKinney, J. A. Horner, G. M. Whitford

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Fluoride is widely used for the prevention of dental caries. Very low concentrations of fluoride are routinely ingested in optimally fluoridated drinking water of many communities. Higher concentrations of fluoride in toothpastes, mouthrinses and topically applied gels also may be ingested, especially by children. The potential effect of ingested fluoride on the gastric mucosa was the subject of this investigation. Solutions of 0, 1, or 10 mM NaF in 0.1 N HCl were placed in rat stomachs in vivo for up to one hour. The effects of fluoride on the structure and function of the gastric mucosa were determined. Histologic and SEM examinations revealed dose‐and time‐dependent damage to the surface mucous cells. The 10 mM, but not the 1 mM, NaF solution increased gastric mucosal permeability to small but not to large molecules.

Original language	English (US)
Pages (from-to)	535-545
Number of pages	11
Journal	Journal of Oral Pathology & Medicine
Volume	13
Issue number	5
DOIs	https://doi.org/10.1111/j.1600-0714.1984.tb01454.x
State	Published - Oct 1984

ASJC Scopus subject areas

Pathology and Forensic Medicine
Oral Surgery
Otorhinolaryngology
Cancer Research
Periodontics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0714.1984.tb01454.x

Cite this

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abstract = "Fluoride is widely used for the prevention of dental caries. Very low concentrations of fluoride are routinely ingested in optimally fluoridated drinking water of many communities. Higher concentrations of fluoride in toothpastes, mouthrinses and topically applied gels also may be ingested, especially by children. The potential effect of ingested fluoride on the gastric mucosa was the subject of this investigation. Solutions of 0, 1, or 10 mM NaF in 0.1 N HCl were placed in rat stomachs in vivo for up to one hour. The effects of fluoride on the structure and function of the gastric mucosa were determined. Histologic and SEM examinations revealed dose‐and time‐dependent damage to the surface mucous cells. The 10 mM, but not the 1 mM, NaF solution increased gastric mucosal permeability to small but not to large molecules.",

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AU - Pashley, D. H.

AU - Allison, N. B.

AU - Easmann, R. P.

AU - McKinney, R. V.

AU - Horner, J. A.

AU - Whitford, G. M.

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AB - Fluoride is widely used for the prevention of dental caries. Very low concentrations of fluoride are routinely ingested in optimally fluoridated drinking water of many communities. Higher concentrations of fluoride in toothpastes, mouthrinses and topically applied gels also may be ingested, especially by children. The potential effect of ingested fluoride on the gastric mucosa was the subject of this investigation. Solutions of 0, 1, or 10 mM NaF in 0.1 N HCl were placed in rat stomachs in vivo for up to one hour. The effects of fluoride on the structure and function of the gastric mucosa were determined. Histologic and SEM examinations revealed dose‐and time‐dependent damage to the surface mucous cells. The 10 mM, but not the 1 mM, NaF solution increased gastric mucosal permeability to small but not to large molecules.

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The effects of fluoride on the gastric mucosa of the rat

Abstract

ASJC Scopus subject areas

UN SDGs

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