The effects of theophylline and 3-isobutyl-1-methylxanthine on the contractility, cyclic AMP content and phosphodiesterase activity of the M. Mercenaria ventricle

Stephen D. Hess; Paul D. Reiss; William J. Higgins

doi:10.1016/0306-4492(81)90095-2

The effects of theophylline and 3-isobutyl-1-methylxanthine on the contractility, cyclic AMP content and phosphodiesterase activity of the M. Mercenaria ventricle

Stephen D. Hess, Paul D. Reiss, William J. Higgins

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Abstract

1. Theophylline and 3-isobutyl-1-methylxanthine (IBMX) are relatively poor inhibitors of cyclic AMP phosphodiesterase from the ventricles of the bivalve Mercenaria mercenaria (I₅₀ = 4.5 × 10^-3 and 2 × 10^-3 M, respectively). 2. At doses ≤10^-4 M, these agents have no effect on myocardial contractility or cyclic AMP content. 3. However, IBMX (10^-4 M) does potentiate the cardio-excitatory actions of a subthreshold of 5-hydroxytryptamine.

Original language	English (US)
Pages (from-to)	13-18
Number of pages	6
Journal	Comparative Biochemistry and Physiology. Part C, Comparative
Volume	69
Issue number	1
DOIs	https://doi.org/10.1016/0306-4492(81)90095-2
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

Immunology
Pharmacology

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10.1016/0306-4492(81)90095-2

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The effects of theophylline and 3-isobutyl-1-methylxanthine on the contractility, cyclic AMP content and phosphodiesterase activity of the M. Mercenaria ventricle. / Hess, Stephen D.; Reiss, Paul D.; Higgins, William J.
In: Comparative Biochemistry and Physiology. Part C, Comparative, Vol. 69, No. 1, 1981, p. 13-18.

Research output: Contribution to journal › Article › peer-review

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abstract = "1. Theophylline and 3-isobutyl-1-methylxanthine (IBMX) are relatively poor inhibitors of cyclic AMP phosphodiesterase from the ventricles of the bivalve Mercenaria mercenaria (I50 = 4.5 × 10-3 and 2 × 10-3 M, respectively). 2. At doses ≤10-4 M, these agents have no effect on myocardial contractility or cyclic AMP content. 3. However, IBMX (10-4 M) does potentiate the cardio-excitatory actions of a subthreshold of 5-hydroxytryptamine.",

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AU - Higgins, William J.

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N2 - 1. Theophylline and 3-isobutyl-1-methylxanthine (IBMX) are relatively poor inhibitors of cyclic AMP phosphodiesterase from the ventricles of the bivalve Mercenaria mercenaria (I50 = 4.5 × 10-3 and 2 × 10-3 M, respectively). 2. At doses ≤10-4 M, these agents have no effect on myocardial contractility or cyclic AMP content. 3. However, IBMX (10-4 M) does potentiate the cardio-excitatory actions of a subthreshold of 5-hydroxytryptamine.

AB - 1. Theophylline and 3-isobutyl-1-methylxanthine (IBMX) are relatively poor inhibitors of cyclic AMP phosphodiesterase from the ventricles of the bivalve Mercenaria mercenaria (I50 = 4.5 × 10-3 and 2 × 10-3 M, respectively). 2. At doses ≤10-4 M, these agents have no effect on myocardial contractility or cyclic AMP content. 3. However, IBMX (10-4 M) does potentiate the cardio-excitatory actions of a subthreshold of 5-hydroxytryptamine.

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The effects of theophylline and 3-isobutyl-1-methylxanthine on the contractility, cyclic AMP content and phosphodiesterase activity of the M. Mercenaria ventricle

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