Abstract
During the past two years, the enzyme responsible for production of endothelium-derived nitric oxide, the endothelial cell NO synthase (ecNOS) has been cloned and the gene encoding this enzyme isolated, cloned and its structure characterized. This research has provided direction for a variety of studies of regulation of the ecNOS. Several features of the ecNOS are compatible with a constitutively expressed, poorly regulated gene, including absence of a TATA box and numerous SP-1 sites. The promoter also contains a number of putative binding domains which suggest that it may be regulated by a variety of transcription factor mediated signals. In this review we will discuss evidence to support the concept that the ecNOS is a constitutively expressed gene subject to a modest degree of regulation by important physiological influences.
Original language | English (US) |
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Pages (from-to) | 107-117 |
Number of pages | 11 |
Journal | Agents and Actions |
Volume | 45 |
Issue number | SUPPL. I |
DOIs | |
State | Published - 1995 |
ASJC Scopus subject areas
- Toxicology
- Pharmacology (medical)