TY - JOUR
T1 - The evolution of care of cancers of the head and neck region
T2 - State of the science in 2020
AU - Yan, Flora
AU - Knochelmann, Hannah M.
AU - Morgan, Patrick F.
AU - Kaczmar, John M.
AU - Neskey, David M.
AU - Graboyes, Evan M.
AU - Nguyen, Shaun A.
AU - Ogretmen, Besim
AU - Sharma, Anand K.
AU - Day, Terry A.
N1 - Funding Information:
B.O. declares research funding from the National Institute of Health/National Institute of Dental and Craniofacial Research, grant number DE016572. D.M.N. declares research funding from the National Institute of Dental and Craniofacial Research, grant number NIDCR K08DE026542. E.M.G. declares research funding from the National Cancer Institute (NCI), grant number K08CA237858, and from the Doris Duke Charitable Foundation, grant number DDCF2015209.). H.M.K. declares research funding from the National Cancer Institute, grant number F30 CA243307 and the National Institute of Health, grant number T32 GM008716.
Funding Information:
Funding: B.O. declares research funding from the National Institute of Health/National Institute of Dental and Craniofacial Research, grant number DE016572. D.M.N. declares research funding from the National Institute of Dental and Craniofacial Research, grant number NIDCR K08DE026542. E.M.G. declares research funding from the National Cancer Institute (NCI), grant number K08CA237858, and from the Doris Duke Charitable Foundation, grant number DDCF2015209.). H.M.K. declares research funding from the National Cancer Institute, grant number F30 CA243307 and the National Institute of Health, grant number T32 GM008716.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/6
Y1 - 2020/6
N2 - Cancers that arise in the head and neck region are comprised of a heterogeneous group of malignancies that include carcinogen-and human papillomavirus (HPV)-driven mucosal squamous cell carcinoma as well as skin cancers such as cutaneous squamous cell carcinoma, basal cell carcinoma, melanoma, and Merkel cell carcinoma. These malignancies develop in critical areas for eating, talking, and breathing and are associated with substantial morbidity and mortality despite advances in treatment. Understanding of advances in the management of these various cancers is important for all multidisciplinary providers who care for patients across the cancer care continuum. Additionally, the recent Coronavirus Disease 2019 (COVID-19) pandemic has necessitated adaptations to head and neck cancer care to accommodate the mitigation of COVID-19 risk and ensure timely treatment. This review explores advances in diagnostic criteria, prognostic factors, and management for subsites including head and neck squamous cell carcinoma and the various forms of skin cancer (basal cell carcinoma, cutaneous squamous cell carcinoma, Merkel cell carcinoma, and melanoma). Then, this review summarizes emerging developments in immunotherapy, radiation therapy, cancer survivorship, and the delivery of care during the COVID-19 era.
AB - Cancers that arise in the head and neck region are comprised of a heterogeneous group of malignancies that include carcinogen-and human papillomavirus (HPV)-driven mucosal squamous cell carcinoma as well as skin cancers such as cutaneous squamous cell carcinoma, basal cell carcinoma, melanoma, and Merkel cell carcinoma. These malignancies develop in critical areas for eating, talking, and breathing and are associated with substantial morbidity and mortality despite advances in treatment. Understanding of advances in the management of these various cancers is important for all multidisciplinary providers who care for patients across the cancer care continuum. Additionally, the recent Coronavirus Disease 2019 (COVID-19) pandemic has necessitated adaptations to head and neck cancer care to accommodate the mitigation of COVID-19 risk and ensure timely treatment. This review explores advances in diagnostic criteria, prognostic factors, and management for subsites including head and neck squamous cell carcinoma and the various forms of skin cancer (basal cell carcinoma, cutaneous squamous cell carcinoma, Merkel cell carcinoma, and melanoma). Then, this review summarizes emerging developments in immunotherapy, radiation therapy, cancer survivorship, and the delivery of care during the COVID-19 era.
KW - COVID-19
KW - Head and neck cancer
KW - Head and neck squamous cell carcinoma
KW - Salivary gland cancer
KW - Skin cancer
KW - Thyroid cancer
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UR - http://www.scopus.com/inward/citedby.url?scp=85086456136&partnerID=8YFLogxK
U2 - 10.3390/cancers12061543
DO - 10.3390/cancers12061543
M3 - Review article
AN - SCOPUS:85086456136
SN - 2072-6694
VL - 12
SP - 1
EP - 24
JO - Cancers
JF - Cancers
IS - 6
M1 - 1543
ER -
