The flow-mediated dilation response to acute exercise in overweight active and inactive men

Ryan A. Harris, Jaume Padilla, Kevin P. Hanlon, Lawrence D. Rink, Janet P. Wallace

Research output: Contribution to journalArticlepeer-review

96 Scopus citations


Objective:Inflammation has been found to play a role in the etiology of cardiovascular disease as well as provoke endothelial dysfunction. Inflammatory cytokines associated with endothelial function are interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). IL-6 is exercise intensity dependent and has been shown to inhibit TNF-α expression directly. The aim of this study was to investigate the interaction of IL-6 and TNF-α on endothelial function in response to acute exercise in overweight men exhibiting different physical activity profiles.Methods and Procedures:Using a randomized mixed factorial design, 16 overweight men (8 active, maximal exercise capacity (VO"2peak) 34.2 ± 1.7, BMI 27.4 ± 0.7 and 8 inactive, VO"2peak 30.9 ± 1.2, BMI 29.3 ± 1.0) performed three different intensity acute exercise treatments. Brachial artery flow-mediated dilation (FMD) and subsequent blood samples were taken pre-exercise and 1 h following the cessation of exercise.Results:Independent of exercise intensity, the active group displayed a 24 increase (P 0.034) in FMD following acute exercise compared to a 32 decrease (P 0.010) in the inactive group. Elevated (P < 0.001) concentrations of IL-6 following moderate (50 VO"2) and high (75 VO"2) intensity acute exercise were observed in both groups; however, concentrations of TNF-α were unchanged in response to acute exercise (P 0.584).Discussion:The FMD response to acute exercise is enhanced in active men who are overweight, whereas inactive men who are overweight exhibit an attenuated response. The interaction of IL-6 and TNF-α did not provide insight into the physiological mechanisms associated with the disparity of FMD observed between groups.

Original languageEnglish (US)
Pages (from-to)578-584
Number of pages7
Issue number3
StatePublished - Mar 2008
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


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