The function of SH2B3 (LNK) in the kidney

Gregory Blass; David L. Mattson; Alexander Staruschenko

doi:10.1152/ajprenal.00373.2016

The function of SH2B3 (LNK) in the kidney

Gregory Blass, David L. Mattson, Alexander Staruschenko

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Recent evidence indicates the adaptor protein SH2B3 has a major role in the progression of renal diseases. SH2B3 is highly expressed by hematopoietic cells and regulates cytokine signaling, inducing cell-specific effects. Additionally, its expression in other cell types suggests that SH2B3 may have a more extensive role within the kidney. Ex vivo studies have determined targets of SH2B3 cell-specific signaling, while in vivo studies have observed the SH2B3 overall affects in the progression of renal diseases. This mini-review covers the function of SH2B3-expressing cell types that contribute to renal pathologies and their regulation by SH2B3.

Original language	English (US)
Pages (from-to)	F682-F685
Journal	American Journal of Physiology - Renal Physiology
Volume	311
Issue number	4
DOIs	https://doi.org/10.1152/ajprenal.00373.2016
State	Published - 2016
Externally published	Yes

Keywords

Hematopoietic
Hypertension
LNK
Lymphocyte
SH2B adaptor protein 3

ASJC Scopus subject areas

Physiology
Urology

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10.1152/ajprenal.00373.2016

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title = "The function of SH2B3 (LNK) in the kidney",

abstract = "Recent evidence indicates the adaptor protein SH2B3 has a major role in the progression of renal diseases. SH2B3 is highly expressed by hematopoietic cells and regulates cytokine signaling, inducing cell-specific effects. Additionally, its expression in other cell types suggests that SH2B3 may have a more extensive role within the kidney. Ex vivo studies have determined targets of SH2B3 cell-specific signaling, while in vivo studies have observed the SH2B3 overall affects in the progression of renal diseases. This mini-review covers the function of SH2B3-expressing cell types that contribute to renal pathologies and their regulation by SH2B3.",

keywords = "Hematopoietic, Hypertension, LNK, Lymphocyte, SH2B adaptor protein 3",

author = "Gregory Blass and Mattson, {David L.} and Alexander Staruschenko",

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doi = "10.1152/ajprenal.00373.2016",

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AU - Blass, Gregory

AU - Mattson, David L.

AU - Staruschenko, Alexander

PY - 2016

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AB - Recent evidence indicates the adaptor protein SH2B3 has a major role in the progression of renal diseases. SH2B3 is highly expressed by hematopoietic cells and regulates cytokine signaling, inducing cell-specific effects. Additionally, its expression in other cell types suggests that SH2B3 may have a more extensive role within the kidney. Ex vivo studies have determined targets of SH2B3 cell-specific signaling, while in vivo studies have observed the SH2B3 overall affects in the progression of renal diseases. This mini-review covers the function of SH2B3-expressing cell types that contribute to renal pathologies and their regulation by SH2B3.

KW - Hematopoietic

KW - Hypertension

KW - LNK

KW - Lymphocyte

KW - SH2B adaptor protein 3

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DO - 10.1152/ajprenal.00373.2016

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The function of SH2B3 (LNK) in the kidney

Abstract

Keywords

ASJC Scopus subject areas

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