The history of lupus erythematosus

Ravi K. Mallavarapu, Edwin W. Grimsley

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


This article explores the history of lupus erythematosus from the origins of the name to the most modern therapeutic advances. The review includes information about the origin of the name "lupus," the first clear description of the skin lesions, the discovery of the systemic and discoid forms, and further advances which define our current view of this illness. The classical descriptions of Hippocrates, Paracelsus, Manardi, Rudolph Virchow, Cazenave, Robert Willan, and Moritz Kaposi are chronologically described. Later, the contributions of Sir William Osler, Jonathan Hutchinson, Sequira and Balean, Kraus and Bohac, Libman and Sacks, Malcolm Hargraves, and Edmund L. Dubois are highlighted. The major breakthroughs of the modern period, including the diagnostic tests, animal models, and genetics, are briefly described. The article ends with the history of drug-induced lupus, diagnostic criteria, and the history of the therapy of lupus erythematosus. With modern therapeutic advances, the mortality rate from lupus erythematosus has decreased substantially. It is hoped that current research will further improve the prognosis of this disease in the near future.

Original languageEnglish (US)
Pages (from-to)896-898
Number of pages3
JournalSouthern medical journal
Issue number9
StatePublished - Sep 2007
Externally publishedYes


  • Advances
  • History
  • Lupus erythematosus
  • Myths

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'The history of lupus erythematosus'. Together they form a unique fingerprint.

Cite this