The immune response of the mouse to lymphocytic choriomeningitis virus. III. Differences of numbers of cytotoxic T lymphocytes in spleens of mice of different strains

Demetrius Moskophidis; Fritz Lehmann-Grube

doi:10.1016/0008-8749(83)90028-X

The immune response of the mouse to lymphocytic choriomeningitis virus. III. Differences of numbers of cytotoxic T lymphocytes in spleens of mice of different strains

Demetrius Moskophidis
, Fritz Lehmann-Grube

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

By use of an accurate procedure for the measurement of relative numbers of murine cytotoxic T lymphocytes (CTL) marked differences of lymphocytic Choriomeningitis virus-specific CTL in spleens were found among mouse strains that ranged from low over intermediate and high to very high, suggesting a gradient of responses rather than distinct classes. Differences were also found between mice sharing the major histocompatibility complex.

Original language	English (US)
Pages (from-to)	279-289
Number of pages	11
Journal	Cellular Immunology
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(83)90028-X
State	Published - Apr 15 1983
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/0008-8749(83)90028-X

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title = "The immune response of the mouse to lymphocytic choriomeningitis virus. III. Differences of numbers of cytotoxic T lymphocytes in spleens of mice of different strains",

abstract = "By use of an accurate procedure for the measurement of relative numbers of murine cytotoxic T lymphocytes (CTL) marked differences of lymphocytic Choriomeningitis virus-specific CTL in spleens were found among mouse strains that ranged from low over intermediate and high to very high, suggesting a gradient of responses rather than distinct classes. Differences were also found between mice sharing the major histocompatibility complex.",

author = "Demetrius Moskophidis and Fritz Lehmann-Grube",

note = "Funding Information: {\textquoteright} This work was supported by the Deutsche Forschungsgemeinschaft. 2 To whom all correspondence should be addressed. {\textquoteright} The Heimich-Pette-Institut is financially supported by Freie und Hansestadt Hamburg and Bundes-ministerium fur Jugend, Familie und Gesundheit, Bonn, Federal Republic of Germany. 4 Abbreviations used: LCM virus, lymphocytic choriomengitis virus; CTL, cytotoxic T lymphocyte(s); PFU, plaque-forming unit(s); IDS,,, 50\% mouse infectious unit(s); IU, infectious unit(s); HBSS, Hanks{\textquoteright} balanced salt solution; MHC, major histocompatibility complex.",

year = "1983",

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doi = "10.1016/0008-8749(83)90028-X",

language = "English (US)",

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T1 - The immune response of the mouse to lymphocytic choriomeningitis virus. III. Differences of numbers of cytotoxic T lymphocytes in spleens of mice of different strains

AU - Moskophidis, Demetrius

AU - Lehmann-Grube, Fritz

N1 - Funding Information: ’ This work was supported by the Deutsche Forschungsgemeinschaft. 2 To whom all correspondence should be addressed. ’ The Heimich-Pette-Institut is financially supported by Freie und Hansestadt Hamburg and Bundes-ministerium fur Jugend, Familie und Gesundheit, Bonn, Federal Republic of Germany. 4 Abbreviations used: LCM virus, lymphocytic choriomengitis virus; CTL, cytotoxic T lymphocyte(s); PFU, plaque-forming unit(s); IDS,,, 50% mouse infectious unit(s); IU, infectious unit(s); HBSS, Hanks’ balanced salt solution; MHC, major histocompatibility complex.

PY - 1983/4/15

Y1 - 1983/4/15

N2 - By use of an accurate procedure for the measurement of relative numbers of murine cytotoxic T lymphocytes (CTL) marked differences of lymphocytic Choriomeningitis virus-specific CTL in spleens were found among mouse strains that ranged from low over intermediate and high to very high, suggesting a gradient of responses rather than distinct classes. Differences were also found between mice sharing the major histocompatibility complex.

AB - By use of an accurate procedure for the measurement of relative numbers of murine cytotoxic T lymphocytes (CTL) marked differences of lymphocytic Choriomeningitis virus-specific CTL in spleens were found among mouse strains that ranged from low over intermediate and high to very high, suggesting a gradient of responses rather than distinct classes. Differences were also found between mice sharing the major histocompatibility complex.

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The immune response of the mouse to lymphocytic choriomeningitis virus. III. Differences of numbers of cytotoxic T lymphocytes in spleens of mice of different strains

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