The impact of computed tomography on early glottic cancer outcomes

Waleed F. Mourad, Kenneth S. Hu, Rania A. Shourbaji, Dan Ishihara, Wilson Lin, Mahesh Kumar, Dukagjin M. Blakaj, Louis B. Harrison

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Purpose: Aim of this study was to evaluate the impact of computed tomography (CT)-based simulation and planning on early glottic cancer outcomes and toxicity. Methods: This is a single-institution retrospective study of 253 patients with T1-2 glottic cancer who underwent radiation therapy (RT) from January 1998-2010. Group A (80%) underwent 2-dimensional RT (2DRT) and group B (20%) 3-dimensional RT (3DRT). 76% of patients in group A and 84% in group B had T1 cancer. The median dose and fraction size were 63 Gy and 2.25 Gy, respectively. Results: With a median follow-up of 83, 93, and 30 months for the whole cohort, group A and B, respectively, the loco-regional control (LRC) was 97.6%. The rate of LRC for T1 disease was 99.5% and for T2 disease 91%. According to the RT modality, rates of LRC were 99.4 and 100% in groups A and B for T1, and 89.8 and 100% for T2. Long-term toxicity was negligible in both groups. Kaplan-Meier Curve showed the 5-year cause-specific survival to be 100%. Chi-square and multivariate analysis tests showed a significant relationship between CT simulation (3DRT) and LRC (p < 0.0001). Conclusion: CT-based simulation and planning provided better LRC and less acute side effects compared to 2DRT.

Original languageEnglish (US)
Pages (from-to)83-86
Number of pages4
Issue number3
StatePublished - Mar 2013
Externally publishedYes


  • Conformal radiotherapy
  • Larynx
  • Squamous cell carcinoma
  • Vocal cord

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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