The impact of computed tomography on early glottic cancer outcomes

Waleed F. Mourad; Kenneth S. Hu; Rania A. Shourbaji; Dan Ishihara; Wilson Lin; Mahesh Kumar; Dukagjin M. Blakaj; Louis B. Harrison

doi:10.1159/000348529

The impact of computed tomography on early glottic cancer outcomes

Waleed F. Mourad, Kenneth S. Hu, Rania A. Shourbaji, Dan Ishihara, Wilson Lin, Mahesh Kumar, Dukagjin M. Blakaj, Louis B. Harrison

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Purpose: Aim of this study was to evaluate the impact of computed tomography (CT)-based simulation and planning on early glottic cancer outcomes and toxicity. Methods: This is a single-institution retrospective study of 253 patients with T1-2 glottic cancer who underwent radiation therapy (RT) from January 1998-2010. Group A (80%) underwent 2-dimensional RT (2DRT) and group B (20%) 3-dimensional RT (3DRT). 76% of patients in group A and 84% in group B had T1 cancer. The median dose and fraction size were 63 Gy and 2.25 Gy, respectively. Results: With a median follow-up of 83, 93, and 30 months for the whole cohort, group A and B, respectively, the loco-regional control (LRC) was 97.6%. The rate of LRC for T1 disease was 99.5% and for T2 disease 91%. According to the RT modality, rates of LRC were 99.4 and 100% in groups A and B for T1, and 89.8 and 100% for T2. Long-term toxicity was negligible in both groups. Kaplan-Meier Curve showed the 5-year cause-specific survival to be 100%. Chi-square and multivariate analysis tests showed a significant relationship between CT simulation (3DRT) and LRC (p < 0.0001). Conclusion: CT-based simulation and planning provided better LRC and less acute side effects compared to 2DRT.

Original language	English (US)
Pages (from-to)	83-86
Number of pages	4
Journal	Onkologie
Volume	36
Issue number	3
DOIs	https://doi.org/10.1159/000348529
State	Published - Mar 2013
Externally published	Yes

Keywords

Conformal radiotherapy
Larynx
Squamous cell carcinoma
Vocal cord

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000348529

Cite this

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title = "The impact of computed tomography on early glottic cancer outcomes",

abstract = "Purpose: Aim of this study was to evaluate the impact of computed tomography (CT)-based simulation and planning on early glottic cancer outcomes and toxicity. Methods: This is a single-institution retrospective study of 253 patients with T1-2 glottic cancer who underwent radiation therapy (RT) from January 1998-2010. Group A (80%) underwent 2-dimensional RT (2DRT) and group B (20%) 3-dimensional RT (3DRT). 76% of patients in group A and 84% in group B had T1 cancer. The median dose and fraction size were 63 Gy and 2.25 Gy, respectively. Results: With a median follow-up of 83, 93, and 30 months for the whole cohort, group A and B, respectively, the loco-regional control (LRC) was 97.6%. The rate of LRC for T1 disease was 99.5% and for T2 disease 91%. According to the RT modality, rates of LRC were 99.4 and 100% in groups A and B for T1, and 89.8 and 100% for T2. Long-term toxicity was negligible in both groups. Kaplan-Meier Curve showed the 5-year cause-specific survival to be 100%. Chi-square and multivariate analysis tests showed a significant relationship between CT simulation (3DRT) and LRC (p < 0.0001). Conclusion: CT-based simulation and planning provided better LRC and less acute side effects compared to 2DRT.",

keywords = "Conformal radiotherapy, Larynx, Squamous cell carcinoma, Vocal cord",

author = "Mourad, {Waleed F.} and Hu, {Kenneth S.} and Shourbaji, {Rania A.} and Dan Ishihara and Wilson Lin and Mahesh Kumar and Blakaj, {Dukagjin M.} and Harrison, {Louis B.}",

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T1 - The impact of computed tomography on early glottic cancer outcomes

AU - Mourad, Waleed F.

AU - Hu, Kenneth S.

AU - Shourbaji, Rania A.

AU - Ishihara, Dan

AU - Lin, Wilson

AU - Kumar, Mahesh

AU - Blakaj, Dukagjin M.

AU - Harrison, Louis B.

PY - 2013/3

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N2 - Purpose: Aim of this study was to evaluate the impact of computed tomography (CT)-based simulation and planning on early glottic cancer outcomes and toxicity. Methods: This is a single-institution retrospective study of 253 patients with T1-2 glottic cancer who underwent radiation therapy (RT) from January 1998-2010. Group A (80%) underwent 2-dimensional RT (2DRT) and group B (20%) 3-dimensional RT (3DRT). 76% of patients in group A and 84% in group B had T1 cancer. The median dose and fraction size were 63 Gy and 2.25 Gy, respectively. Results: With a median follow-up of 83, 93, and 30 months for the whole cohort, group A and B, respectively, the loco-regional control (LRC) was 97.6%. The rate of LRC for T1 disease was 99.5% and for T2 disease 91%. According to the RT modality, rates of LRC were 99.4 and 100% in groups A and B for T1, and 89.8 and 100% for T2. Long-term toxicity was negligible in both groups. Kaplan-Meier Curve showed the 5-year cause-specific survival to be 100%. Chi-square and multivariate analysis tests showed a significant relationship between CT simulation (3DRT) and LRC (p < 0.0001). Conclusion: CT-based simulation and planning provided better LRC and less acute side effects compared to 2DRT.

AB - Purpose: Aim of this study was to evaluate the impact of computed tomography (CT)-based simulation and planning on early glottic cancer outcomes and toxicity. Methods: This is a single-institution retrospective study of 253 patients with T1-2 glottic cancer who underwent radiation therapy (RT) from January 1998-2010. Group A (80%) underwent 2-dimensional RT (2DRT) and group B (20%) 3-dimensional RT (3DRT). 76% of patients in group A and 84% in group B had T1 cancer. The median dose and fraction size were 63 Gy and 2.25 Gy, respectively. Results: With a median follow-up of 83, 93, and 30 months for the whole cohort, group A and B, respectively, the loco-regional control (LRC) was 97.6%. The rate of LRC for T1 disease was 99.5% and for T2 disease 91%. According to the RT modality, rates of LRC were 99.4 and 100% in groups A and B for T1, and 89.8 and 100% for T2. Long-term toxicity was negligible in both groups. Kaplan-Meier Curve showed the 5-year cause-specific survival to be 100%. Chi-square and multivariate analysis tests showed a significant relationship between CT simulation (3DRT) and LRC (p < 0.0001). Conclusion: CT-based simulation and planning provided better LRC and less acute side effects compared to 2DRT.

KW - Conformal radiotherapy

KW - Larynx

KW - Squamous cell carcinoma

KW - Vocal cord

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The impact of computed tomography on early glottic cancer outcomes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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