The impact of stroke on bone properties and muscle-bone relationship: a systematic review and meta-analysis

F. Z. Yang, D. A.M. Jehu, H. Ouyang, F. M.H. Lam, M. Y.C. Pang

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


To systematically review available evidence related to the characteristics of bone changes post-stroke and the relationship between various aspects of muscle function (e.g., strength, spasticity) and bone properties after stroke onset. An extensive online database search was undertaken (last search in January 2019). Articles that examined the bone properties in stroke patients were included. The quality of the studies was evaluated with the National Institutes of Health (NIH) Study Quality Assessment Tools. Publication bias of meta-analyses was assessed using the Egger’s regression asymmetry test. The selection and evaluation of the articles were conducted by two independent researchers. Fifty-nine studies were identified. In subacute and chronic stroke studies, the skeletal sites in the paretic limbs sustained a more pronounced decline in bone quality than did their counterparts in the non-paretic limbs. The rate of changes showed a decelerating trend as post-stroke duration increased, but the timing of achieving the steady rate differed across skeletal sites. The magnitude of bone changes in the paretic upper limb was more pronounced than the paretic lower limb. There was a strong relationship between muscle strength/mass and bone density/strength index. Muscle spasticity seemed to have a negative impact on bone integrity in the paretic upper limb, but its influence on bone properties in the paretic lower limb was uncertain. Substantial bone changes in the paretic limbs occurred particularly in the first few months after stroke onset. Early intervention, muscle strength training, and long-term management strategies may be important to enhance bone health post-stroke. This review has also revealed the knowledge gaps which should be addressed in future research.

Original languageEnglish (US)
Pages (from-to)211-224
Number of pages14
JournalOsteoporosis International
Issue number2
StatePublished - Feb 1 2020
Externally publishedYes


  • Bone properties
  • Muscle function
  • Muscle spasticity
  • Osteoporosis
  • Stroke

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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