The influence of pregnancy on heterotopic ossification post-displaced acetabular fractures surgical repair

Waleed F. Mourad, Satya Packianathan, Rania A. Shourbaji, Richard Jennelle, Claus Yang, Paul Mobit, Zhen Zhang, Majid A. Khan, Mathew Graves, George Russell, Srinivasan Vijayakumar

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Pregnancy is associated with maternal bone mineral density loss and modulation of calcium metabolism. We hypothesized that pregnancy may decrease the risk of heterotopic ossification (HO) after trauma. This is a single-institution, University of Mississippi Medical Center, retrospective study investigating the effect of pregnancy on the incidence HO after surgical repair (SR) of displaced acetabular fractures. Between January 1998 and 2010, 257 non-pregnant women (Group A) and 16 pregnant women (Group B) were identified. All the non-pregnant women received radiation therapy (RT) ± indomethacin. None of the pregnant women in group B received any prophylaxis. After a median follow-up of 6.6 years the incidence of HO in all patients was 27% (75/273). In Group A, non-pregnant, women who received RT ± indomethacin, 29% developed HO; HO risk was 0.4. In Group B, 16 pregnant patients, only one developed HO (6%); HO risk was 0.06. Thus, the risk of HO appears to be nearly six-fold higher in non-pregnant women despite prophylactic RT ± indomethacin. Our data suggest that pregnancy may be associated with a reduced risk of HO after SR of displaced acetabular fractures. Further analysis with a larger pregnant patient sample is necessary to confirm this finding.

Original languageEnglish (US)
Pages (from-to)944-948
Number of pages5
JournalJournal of Orthopaedic Research
Issue number6
StatePublished - Jun 2013
Externally publishedYes


  • displaced acetabular fracture
  • heterotopic ossification (HO)
  • indomethacin
  • pregnancy
  • radiation therapy (RT)

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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