Abstract
The ability of the classic tumour-suppressive let-7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream-targeted mRNAs, let-7 affected most aspects of cell biology. It is perplexing how let-7 affects oncogenesis, as the large influx of new miRNAs and other kinds of non-coding RNAs are continuously defined. In this review, we delineate the complex functions of let-7 and discuss the future direction of let-7 research.
Original language | English (US) |
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Pages (from-to) | 1779-1788 |
Number of pages | 10 |
Journal | Journal of Cellular and Molecular Medicine |
Volume | 20 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2016 |
Keywords
- DNA methylation
- Let-7 miRNAs
- anti-cancer research
- cancer stem cells
- clinical application
- non-coding RNAs
- regulatory loops
ASJC Scopus subject areas
- Molecular Medicine
- Cell Biology