The kinetics of estrogen binding to rat α-fetoprotein

B. A. Keel; T. O. Abney

doi:10.1007/BF01952408

The kinetics of estrogen binding to rat α-fetoprotein

B. A. Keel, T. O. Abney

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Fluid obtained from rat fetuses was utilized to characterize the affinity, number of binding sites, and the association and dissociation rate kinetics of the binding of estradiol and estrone to AFP. Statistical analysis demonstrated no differences when the values for the AFP-estradiol interaction were compared with those obtained for the AFP-estrone interaction. These data demonstrate that rat AFP specifically binds estradiol and estrone with a high capacity, high affinity, and similar binding kinetics.

Original language	English (US)
Pages (from-to)	503-505
Number of pages	3
Journal	Experientia
Volume	40
Issue number	5
DOIs	https://doi.org/10.1007/BF01952408
State	Published - May 1984

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/BF01952408

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title = "The kinetics of estrogen binding to rat α-fetoprotein",

abstract = "Fluid obtained from rat fetuses was utilized to characterize the affinity, number of binding sites, and the association and dissociation rate kinetics of the binding of estradiol and estrone to AFP. Statistical analysis demonstrated no differences when the values for the AFP-estradiol interaction were compared with those obtained for the AFP-estrone interaction. These data demonstrate that rat AFP specifically binds estradiol and estrone with a high capacity, high affinity, and similar binding kinetics.",

author = "Keel, {B. A.} and Abney, {T. O.}",

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AU - Abney, T. O.

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N2 - Fluid obtained from rat fetuses was utilized to characterize the affinity, number of binding sites, and the association and dissociation rate kinetics of the binding of estradiol and estrone to AFP. Statistical analysis demonstrated no differences when the values for the AFP-estradiol interaction were compared with those obtained for the AFP-estrone interaction. These data demonstrate that rat AFP specifically binds estradiol and estrone with a high capacity, high affinity, and similar binding kinetics.

AB - Fluid obtained from rat fetuses was utilized to characterize the affinity, number of binding sites, and the association and dissociation rate kinetics of the binding of estradiol and estrone to AFP. Statistical analysis demonstrated no differences when the values for the AFP-estradiol interaction were compared with those obtained for the AFP-estrone interaction. These data demonstrate that rat AFP specifically binds estradiol and estrone with a high capacity, high affinity, and similar binding kinetics.

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The kinetics of estrogen binding to rat α-fetoprotein

Abstract

ASJC Scopus subject areas

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