The leptin hypothesis of depression: a potential link between mood disorders and obesity?

Xin Yun Lu

doi:10.1016/j.coph.2007.10.010

The leptin hypothesis of depression: a potential link between mood disorders and obesity?

Xin Yun Lu

Research output: Contribution to journal › Review article › peer-review

249 Scopus citations

Abstract

The adipose-derived hormone leptin is well known for its function in the control of energy homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of mood and emotion. Low levels of leptin have been found to be associated with depressive behaviors in rodents and humans. Pharmacological studies indicate that leptin has antidepressant-like efficacy. Both leptin insufficiency and leptin resistance may contribute to alterations of affective status. Identifying the key brain regions that mediate leptin's antidepressant activity and dissecting its intracellular signal transduction pathways may provide new insights into the pathogenesis of depression and facilitate the development of novel therapeutic strategies for the treatment of this illness.

Original language	English (US)
Pages (from-to)	648-652
Number of pages	5
Journal	Current Opinion in Pharmacology
Volume	7
Issue number	6
DOIs	https://doi.org/10.1016/j.coph.2007.10.010
State	Published - Dec 2007
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.coph.2007.10.010

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@article{02c3d4842f484e2e941759ab55391daa,

title = "The leptin hypothesis of depression: a potential link between mood disorders and obesity?",

abstract = "The adipose-derived hormone leptin is well known for its function in the control of energy homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of mood and emotion. Low levels of leptin have been found to be associated with depressive behaviors in rodents and humans. Pharmacological studies indicate that leptin has antidepressant-like efficacy. Both leptin insufficiency and leptin resistance may contribute to alterations of affective status. Identifying the key brain regions that mediate leptin's antidepressant activity and dissecting its intracellular signal transduction pathways may provide new insights into the pathogenesis of depression and facilitate the development of novel therapeutic strategies for the treatment of this illness.",

author = "Lu, {Xin Yun}",

note = "Funding Information: Preparation of this review and our research cited in this article were supported by grants from the National Institute of Mental Health (NIMH073844 and NIMH076929) and American Heart Association (AHA0530345N). The author would like to thank Alan Frazer and Bai Lu for their comments on the manuscript.",

year = "2007",

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language = "English (US)",

volume = "7",

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T1 - The leptin hypothesis of depression

T2 - a potential link between mood disorders and obesity?

AU - Lu, Xin Yun

N1 - Funding Information: Preparation of this review and our research cited in this article were supported by grants from the National Institute of Mental Health (NIMH073844 and NIMH076929) and American Heart Association (AHA0530345N). The author would like to thank Alan Frazer and Bai Lu for their comments on the manuscript.

PY - 2007/12

Y1 - 2007/12

N2 - The adipose-derived hormone leptin is well known for its function in the control of energy homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of mood and emotion. Low levels of leptin have been found to be associated with depressive behaviors in rodents and humans. Pharmacological studies indicate that leptin has antidepressant-like efficacy. Both leptin insufficiency and leptin resistance may contribute to alterations of affective status. Identifying the key brain regions that mediate leptin's antidepressant activity and dissecting its intracellular signal transduction pathways may provide new insights into the pathogenesis of depression and facilitate the development of novel therapeutic strategies for the treatment of this illness.

AB - The adipose-derived hormone leptin is well known for its function in the control of energy homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of mood and emotion. Low levels of leptin have been found to be associated with depressive behaviors in rodents and humans. Pharmacological studies indicate that leptin has antidepressant-like efficacy. Both leptin insufficiency and leptin resistance may contribute to alterations of affective status. Identifying the key brain regions that mediate leptin's antidepressant activity and dissecting its intracellular signal transduction pathways may provide new insights into the pathogenesis of depression and facilitate the development of novel therapeutic strategies for the treatment of this illness.

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DO - 10.1016/j.coph.2007.10.010

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JO - Current Opinion in Pharmacology

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The leptin hypothesis of depression: a potential link between mood disorders and obesity?

Abstract

ASJC Scopus subject areas

UN SDGs

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