The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families

Jinying Zhao; Heng Wang; Momiao Xiong; Wei Huang; Jin Zuo; Zhu Chen; Boqin Qiang; Qi Sun; Yuxiu Li; Qiuying Liu; Weinan Du; Jialun Chen; Wei Ding; Wentao Yuan; Yang Zhao; Hongyan Xu; Li Jin; Fude Fang

doi:10.1007/BF02886269

The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families

Jinying Zhao, Heng Wang, Momiao Xiong, Wei Huang, Jin Zuo, Zhu Chen, Boqin Qiang, Qi Sun, Yuxiu Li, Qiuying Liu, Weinan Du, Jialun Chen, Wei Ding, Wentao Yuan, Yang Zhao, Hongyan Xu, Li Jin, Fude Fang

Biostats & Data Science

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.

Original language	English (US)
Pages (from-to)	1792-1795
Number of pages	4
Journal	Chinese Science Bulletin
Volume	45
Issue number	19
DOIs	https://doi.org/10.1007/BF02886269
State	Published - 2000

Keywords

Northern Han Chinese
Susceptibility gene locus
Type 2 diabetes

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10.1007/BF02886269

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title = "The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families",

abstract = "We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.",

keywords = "Northern Han Chinese, Susceptibility gene locus, Type 2 diabetes",

author = "Jinying Zhao and Heng Wang and Momiao Xiong and Wei Huang and Jin Zuo and Zhu Chen and Boqin Qiang and Qi Sun and Yuxiu Li and Qiuying Liu and Weinan Du and Jialun Chen and Wei Ding and Wentao Yuan and Yang Zhao and Hongyan Xu and Li Jin and Fude Fang",

note = "Funding Information: Acknowledgements This work was supported by the National {"}973{"} Project and the National {"}863{"} High-Tech Project (Grant Nos. 102-10-02-02 and Z 19-0 1 -02-02).",

year = "2000",

doi = "10.1007/BF02886269",

language = "English (US)",

volume = "45",

pages = "1792--1795",

journal = "Chinese Science Bulletin",

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TY - JOUR

T1 - The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families

AU - Zhao, Jinying

AU - Wang, Heng

AU - Xiong, Momiao

AU - Huang, Wei

AU - Zuo, Jin

AU - Chen, Zhu

AU - Qiang, Boqin

AU - Sun, Qi

AU - Li, Yuxiu

AU - Liu, Qiuying

AU - Du, Weinan

AU - Chen, Jialun

AU - Ding, Wei

AU - Yuan, Wentao

AU - Zhao, Yang

AU - Xu, Hongyan

AU - Jin, Li

AU - Fang, Fude

N1 - Funding Information: Acknowledgements This work was supported by the National "973" Project and the National "863" High-Tech Project (Grant Nos. 102-10-02-02 and Z 19-0 1 -02-02).

PY - 2000

Y1 - 2000

N2 - We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.

AB - We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.

KW - Northern Han Chinese

KW - Susceptibility gene locus

KW - Type 2 diabetes

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JO - Chinese Science Bulletin

JF - Chinese Science Bulletin

IS - 19

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The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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